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One such tethering factor is called TRAnsport Protein Particle (TRAPP), and in humans, TRAPP proteins are distributed into two related complexes called TRAPP II and III. Although thought to act as a single unit within the complex, in the past few years it has become evident that some TRAPP proteins function independently of the complex. Consistent with this, variations in the genes encoding these proteins result in a spectrum of human diseases with diverse, but partially overlapping, phenotypes. This contrasts with other tethering factors such as COG, where variations in the genes that encode its subunits all result in an identical phenotype. In this review, we present an up\u2010to\u2010date summary of all the known disease\u2010related variations of genes encoding TRAPP\u2010associated proteins and the disorders linked to these variations which we now call TRAPPopathies.<\/jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tra12615-gra-0001.png\" xlink:title=\"image\"\/><\/jats:p>","DOI":"10.1111\/tra.12615","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T21:35:36Z","timestamp":1535578536000},"page":"5-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)\u2010associated 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