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LBPA is abundant in the membrane system present in the lumen of this compartment, including intralumenal vesicles (ILVs). In this review, the current knowledge on LBPA and LBPA\u2010containing membranes will be summarized, and their role in the control of endosomal cholesterol will be outlined. Some speculations will also be made on how this system may be overwhelmed in the cholesterol storage disorder Niemann\u2010Pick C. Then, the roles of intralumenal membranes in endo\u2010lysosomal dynamics and functions will be discussed in broader terms. Likewise, the mechanisms that drive the biogenesis of intralumenal membranes, including ESCRTs, will also be discussed, as well as their diverse composition and fate, including degradation in lysosomes and secretion as exosomes. This review will also discuss how intralumenal membranes are hijacked by pathogenic agents during intoxication and infection, and what is the biochemical composition and function of the intra\u2010endosomal lumenal milieu. Finally, this review will allude to the size limitations imposed on intralumenal vesicle functions and speculate on the possible role of LBPA as calcium chelator in the acidic calcium stores of endo\u2010lysosomes.<\/jats:p>","DOI":"10.1111\/tra.12715","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T12:33:07Z","timestamp":1572957187000},"page":"76-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":236,"title":["Life in the lumen: The multivesicular endosome"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0300-4862","authenticated-orcid":false,"given":"Jean","family":"Gruenberg","sequence":"first","affiliation":[{"name":"Biochemistry Department University of Geneva  Geneva 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