{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:38:22Z","timestamp":1791272302439,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008231","name":"Arkansas Biosciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In filamentous fungi, early endosomes are continuously trafficked to, and from, the growing hyphal tip by microtubule\u2010based motor proteins, serving as platforms for the long\u2010distance transport of diverse cargos including mRNA, signaling molecules, and other organelles which hitchhike on them. While the cellular machinery for early endosome motility in filamentous fungi is fairly well characterized, the broader physiological significance of this process remains less well understood. We set out to determine the importance of long\u2010distance early endosome trafficking in\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    , an opportunistic human pathogenic fungus that can cause devastating pulmonary infections in immunocompromised individuals. We first characterized normal early endosome motile behavior in\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    , then generated a mutant in which early endosome motility is severely perturbed through targeted deletion of the gene encoding for FtsA, one of a complex of proteins that links early endosomes to their motor proteins. Using a microfluidics\u2010based approach we show that contact\u2010induced hyphal branching behaviors are impaired in \u0394\n                    <jats:italic>ftsA<\/jats:italic>\n                    mutants, but that FtsA\u2010mediated early endosome motility is dispensable for virulence in an invertebrate infection model. Overall, our study provides new insight into early endosome motility in an important human pathogenic fungus.\n                  <\/jats:p>","DOI":"10.1111\/tra.12735","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T06:14:11Z","timestamp":1588832051000},"page":"479-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010distance early endosome motility in\n                    <i>Aspergillus fumigatus<\/i>\n                    promotes normal hyphal growth behaviors in controlled microenvironments but is dispensable for virulence"],"prefix":"10.1111","volume":"21","author":[{"given":"Baronger Dowell","family":"Bieger","sequence":"first","affiliation":[{"name":"Department of Entomology and Plant Pathology University of Arkansas Systems Division of Agriculture  Fayetteville Arkansas USA"},{"name":"Cell and Molecular Biology Program University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audra Mae","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Entomology and Plant Pathology University of Arkansas Systems Division of Agriculture  Fayetteville Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Bates","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Medical Mycology at the University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-8745","authenticated-orcid":false,"given":"Martin John","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Entomology and Plant Pathology University of Arkansas Systems Division of Agriculture  Fayetteville Arkansas USA"},{"name":"Cell and Molecular Biology Program University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201308009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201309022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e14-04-0873"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201112101"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201512020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e13-09-0557"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00848.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf296"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601119"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e05-04-0272"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuw021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1618"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6097"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201505086"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.09.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/embr.201338037"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.182824"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201307164"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.2.310"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3034-3042.2003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.2.891-903.2003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"issue":"3","key":"e_1_2_6_24_1","first-page":"517511","article-title":"Hyphal growth in human fungal pathogens and its role in virulence","volume":"2012","author":"Brand A","year":"2012","journal-title":"Int J Microbiol"},{"issue":"2","key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/microbiolspec.FUNK-0040-2016","article-title":"Thigmo responses: the fungal sense of touch","volume":"5","author":"Almeida MC","year":"2017","journal-title":"Microbiol Spectr"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-08-0566"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16163-1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006154"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2019.02.012"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0561-14.2014"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1776"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.10.003"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3852\/08-177"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2017.00033"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.2.225-229.2005"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816423116"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-02-0119"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-11-0925"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007291"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.06021.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25016-4"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000200"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00288-10"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.523852"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002145"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(83)01017-4"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.3.2.527-535.2004"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e15-06-0404"}],"container-title":["Traffic"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftra.12735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tra.12735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tra.12735","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tra.12735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T01:23:14Z","timestamp":1693963394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tra.12735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/tra.12735"],"URL":"https:\/\/doi.org\/10.1111\/tra.12735","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/TRA.12735\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12735\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1398-9219","1600-0854"],"issn-type":[{"value":"1398-9219","type":"print"},{"value":"1600-0854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]},"assertion":[{"value":"2019-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}