{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:15:05Z","timestamp":1773101705885,"version":"3.50.1"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"am","delay-in-days":333,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP160101573"],"award-info":[{"award-number":["DP160101573"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210103017"],"award-info":[{"award-number":["DP210103017"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1037320"],"award-info":[{"award-number":["APP1037320"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1041929"],"award-info":[{"award-number":["APP1041929"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1045092"],"award-info":[{"award-number":["APP1045092"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1058565"],"award-info":[{"award-number":["APP1058565"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP569542"],"award-info":[{"award-number":["APP569542"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Retromer core complex is an endosomal scaffold that plays a critical role in orchestrating protein trafficking within the endosomal system. Here we characterized the effect of the Parkinson's disease\u2010linked Vps35 D620N in the endo\u2010lysosomal system using Vps35 D620N rescue cell models. Vps35 D620N fully rescues the lysosomal and autophagy defects caused by retromer knock\u2010out. Analogous to Vps35 knock out cells, the endosome\u2010to\u2010trans\u2010Golgi network transport of cation\u2010independent mannose 6\u2010phosphate receptor (CI\u2010M6PR) is impaired in Vps35 D620N rescue cells because of a reduced capacity to form endosome transport carriers. Cells expressing the Vps35 D620N variant have altered endosomal morphology, resulting in smaller, rounder structures with less tubule\u2010like branches. At the molecular level retromer incorporating Vps35 D620N variant has a decreased binding to retromer associated proteins wiskott\u2013aldrich syndrome protein and SCAR homologue (WASH) and SNX3 which are known to associate with retromer to form the endosome transport carriers. Hence, the partial defects on retrograde protein trafficking carriers in the presence of Vps35 D620N represents an altered cellular state able to cause Parkinson's disease.<\/jats:p>","DOI":"10.1111\/tra.12779","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T08:32:26Z","timestamp":1608625946000},"page":"123-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Formation of retromer transport carriers is disrupted by the Parkinson disease\u2010linked Vps35\n                    <scp>D620N<\/scp>\n                    variant"],"prefix":"10.1111","volume":"22","author":[{"given":"Yi","family":"Cui","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neftali","family":"Flores\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Follett","sequence":"additional","affiliation":[{"name":"Institute for Molecular Biosciences and Centre for Microscopy and Microanalysis The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Ariotti","sequence":"additional","affiliation":[{"name":"Institute for Molecular Biosciences and Centre for Microscopy and Microanalysis The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam A.","family":"Wall","sequence":"additional","affiliation":[{"name":"Institute for Molecular Biosciences and Centre for Microscopy and Microanalysis The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-5248","authenticated-orcid":false,"given":"Robert G.","family":"Parton","sequence":"additional","affiliation":[{"name":"Institute for Molecular Biosciences and Centre for Microscopy and Microanalysis The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7455-5269","authenticated-orcid":false,"given":"Rohan D.","family":"Teasdale","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Medicine The University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2011.01284.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00777.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2007.00652.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06216"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2005.00328.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.103440"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312055"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201806153"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2004411"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00757-11"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.06.024"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2012.01374.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.07.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2015.03.018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312034"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.009654"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.217398"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx321"},{"issue":"1","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1242\/jcs.03302","article-title":"Cullen PJ. A loss\u2010of\u2010function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer","volume":"120","author":"Wassmer T","year":"2007","journal-title":"J Cell Sci"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200812042"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.018"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410552111"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.196758"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2721"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.05.016"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12309"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.06.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.06.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12136"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20180248"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12931"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-018-0063-3"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814909116"},{"issue":"20","key":"e_1_2_9_35_1","first-page":"4507","article-title":"Impaired striatal dopamine release in homozygous Vps35 D620N knock\u2010in mice","volume":"25","author":"Ishizu N","year":"2016","journal-title":"Hum Mol Genet"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797128"},{"issue":"3","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/cm.20437","article-title":"WASH and the Arp2\/3 complex regulate endosome shape and trafficking","volume":"67","author":"Duleh SN","year":"2010","journal-title":"Cytoskeleton (Hoboken)"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00163"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111761"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-12-1059"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12406"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.071472"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201200038"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13305"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.056"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.156299"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.048686"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4828"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy224"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.051"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.201905"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2281"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316482111"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03370-1"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.05.020"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0526-z"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256898"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.12.001"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.3367"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101155"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.10.032"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.11.013"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-2-5"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.22709"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi800699v"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130230"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5311-12.2013"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467208666150507103716"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3885-16.2017"},{"key":"e_1_2_9_70_1","first-page":"7049108","article-title":"Parkinson's Disease: The Mitochondria\u2010Iron Link","volume":"2016","author":"Munoz Y","year":"2016","journal-title":"Parkinsons Dis"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000735"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2272-7_3"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14729"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.6.3259"}],"container-title":["Traffic"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tra.12779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tra.12779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/tra.12779","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tra.12779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T17:58:02Z","timestamp":1724090282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tra.12779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,22]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/tra.12779"],"URL":"https:\/\/doi.org\/10.1111\/tra.12779","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/TRA.12779\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12779\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12779\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12779\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.12779\/v1\/review1","asserted-by":"object"}]},"ISSN":["1398-9219","1600-0854"],"issn-type":[{"value":"1398-9219","type":"print"},{"value":"1600-0854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,22]]},"assertion":[{"value":"2020-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}