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Extracellular vesicles (EVs) are vital to the biology of <jats:italic>P. falciparum<\/jats:italic> and play a role in the pathogenesis of malaria. Recent studies have also shown that EVs may play a role in the development of artemisinin resistance in <jats:italic>P. falciparum<\/jats:italic>. Here, we highlight evidence on EVs in <jats:italic>P. falciparum<\/jats:italic> biology and malaria pathogenesis and argue that there is sufficient ground to propose a role for EVs in the development of <jats:italic>P. falciparum<\/jats:italic> artemisinin resistance. We suggest that EVs are actively secreted functional organelles that contribute to cellular homeostasis in <jats:italic>P. falciparum<\/jats:italic>\u2010infected red blood cells under artemisinin pressure. Further exploration of this hypothesized EVs\u2010based molecular mechanism of artemisinin resistance will aid the discovery of novel antimalarial therapies.<\/jats:p>","DOI":"10.1111\/tra.12787","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T20:06:52Z","timestamp":1618603612000},"page":"194-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Implicating extracellular vesicles in <scp><i>Plasmodium falciparum<\/i><\/scp> artemisinin resistance development"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-2845","authenticated-orcid":false,"given":"Kwesi Z.","family":"Tandoh","sequence":"first","affiliation":[{"name":"West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences University of Ghana  Accra 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