{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:05Z","timestamp":1787016065994,"version":"build-2736575974"},"reference-count":102,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1092789"],"award-info":[{"award-number":["1092789"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["119780521"],"award-info":[{"award-number":["119780521"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence that greatly assist parasite survival. As resistance to all current antimalarial compounds is rising new compounds need to be identified and those that could inhibit parasite protein secretion and export would both rapidly reduce parasite virulence and ultimately lead to parasite death. To identify compounds that inhibit protein export we used transgenic parasites expressing an exported nanoluciferase reporter to screen the Medicines for Malaria Venture Malaria Box of 400 antimalarial compounds with mostly unknown targets. The most potent inhibitor identified in this screen was MMV396797 whose application led to export inhibition of both the reporter and endogenous exported proteins. MMV396797 mediated blockage of protein export and slowed the rigidification and cytoadherence of infected RBCs\u2014modifications which are both mediated by parasite\u2010derived exported proteins. Overall, we have identified a new protein export inhibitor in\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    whose target though unknown, could be developed into a future antimalarial that rapidly inhibits parasite virulence before eliminating parasites from the host.\n                  <\/jats:p>","DOI":"10.1111\/tra.12862","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T07:59:30Z","timestamp":1659254370000},"page":"442-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in\n                    <i>Plasmodium falciparum<\/i>\n                    blood stage parasites"],"prefix":"10.1111","volume":"23","author":[{"given":"Oliver","family":"Looker","sequence":"first","affiliation":[{"name":"Burnet Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline G.","family":"Dans","sequence":"additional","affiliation":[{"name":"Burnet Institute  Melbourne Australia"},{"name":"School of Medicine Deakin University  Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley E.","family":"Bullen","sequence":"additional","affiliation":[{"name":"Burnet Institute  Melbourne Australia"},{"name":"Department of Immunology and Microbiology University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad E.","family":"Sleebs","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research  Parkville Australia"},{"name":"Department of Medical Biology The University of Melbourne  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan S.","family":"Crabb","sequence":"additional","affiliation":[{"name":"Burnet Institute  Melbourne Australia"},{"name":"Department of Immunology and Microbiology University of Melbourne  Melbourne Australia"},{"name":"Department of Immunology and Pathology Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Gilson","sequence":"additional","affiliation":[{"name":"Burnet Institute  Melbourne Australia"},{"name":"Department of Immunology and Microbiology University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"World Malaria Report 2021","year":"2021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30048-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009133"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66277"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-020-06786-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09107"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09099"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211936"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062906"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00379-17"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20629-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz443"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006180"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37502"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01226-16"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29317"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1231-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16414"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2015.05.003"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115859"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12765"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105817"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2020.01.002"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00534-17"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12782"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.0c00078"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306097110"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad9735"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2012.09.007"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102452"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102737"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155730"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08728"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.04.011"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08104"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13555"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.09.008"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13574"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001897"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3061"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.073"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.328591"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0469-4"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08726"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009977"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.002"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093759"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2014.10.004"},{"issue":"3","key":"e_1_2_11_51_1","article-title":"CLAG3 self\u2010associates in malaria parasites and quantitatively determines nutrient uptake channels at the host membrane","volume":"9","author":"Gupta A","year":"2018","journal-title":"MBio"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1505584112"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/415673a"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01233-13"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2012.026"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0981-7_12"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa368"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.05.022"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112571"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16044"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(97)00134-5"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/360352a0"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/108705719900400206"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.1170060207"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026023393354"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013000292"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12577"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00864.x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-250399"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007761"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4624"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2021.04.009"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7847"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.1060"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-312801"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.6.1567"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.4.1307"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.348839"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400466"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1086\/428137"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01224-16"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv372"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.1.61"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11901"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4472"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1870413"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193225"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.2.377"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0222-7"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsu009"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115174"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006552"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01265"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3001373"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005763"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0962-2"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003257"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-187"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.4040.bloodjournal88104040"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13332"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1978.11719283"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.2307\/3281203"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.739"}],"container-title":["Traffic"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tra.12862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tra.12862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tra.12862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T10:45:25Z","timestamp":1692787525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tra.12862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":102,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/tra.12862"],"URL":"https:\/\/doi.org\/10.1111\/tra.12862","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.01.490233","asserted-by":"object"}]},"ISSN":["1398-9219","1600-0854"],"issn-type":[{"value":"1398-9219","type":"print"},{"value":"1600-0854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]},"assertion":[{"value":"2022-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}