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Among the various IFT proteins, intraflagellar transport 52 (IFT52) plays a crucial role in ciliary transport and is implicated in various ciliopathies. IFT52 is a core component of the IFT\u2010B complex that facilitates movement of cargoes along the ciliary axoneme. Stable binding of the IFT\u2010B1 and IFT\u2010B2 subcomplexes by IFT52 in the IFT\u2010B complex regulates recycling of ciliary components and maintenance of ciliary functions such as signal transduction and molecular movement. Mutations in the<jats:italic>IFT52<\/jats:italic>gene can disrupt ciliary trafficking, resulting in dysfunctional cilia and affecting cellular processes in ciliopathies. Such ciliopathies caused by<jats:italic>IFT52<\/jats:italic>mutations exhibit a wide range of clinical features, including skeletal developmental abnormalities, retinal degeneration, respiratory failure and neurological abnormalities in affected individuals. Therefore, IFT52 serves as a promising biomarker for the diagnosis of various ciliopathies, including short\u2010rib thoracic dysplasia 16 with or without polydactyly. Here, we provide an overview of the IFT52\u2010mediated molecular mechanisms underlying ciliary transport and describe the<jats:italic>IFT52<\/jats:italic>mutations that cause different disorders associated with cilia dysfunction.<\/jats:p>","DOI":"10.1111\/tra.12929","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T06:25:40Z","timestamp":1705040740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The emerging functions of intraflagellar transport 52 in ciliary transport and ciliopathies"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-5141","authenticated-orcid":false,"given":"Prajna","family":"Udupa","sequence":"first","affiliation":[{"name":"Kasturba Medical College, Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-0685","authenticated-orcid":false,"given":"Debasish Kumar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Kasturba Medical College, Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.019"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.040705.141236"},{"key":"e_1_2_13_4_1","first-page":"9","volume-title":"Axoneme Structure from Motile Cilia","author":"Ishikawa 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