{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:42:11Z","timestamp":1786372931731,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"4-6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Intracellular pathogens rely on manipulating host endocytic pathways to ensure survival.\n                    <jats:italic>Legionella<\/jats:italic>\n                    and\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    exploit host SNARE proteins, with\n                    <jats:italic>Legionella<\/jats:italic>\n                    cleaving syntaxin 17 (STX17) and\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    interacting with VAMP8 and VAMP7. Similarly,\n                    <jats:italic>Salmonella<\/jats:italic>\n                    targets the host's endosomal fusion machinery, using SPI effectors like SipC and SipA to interact with syntaxin 6 (STX6) and syntaxin 8 (STX8), respectively, maintaining its vacuolar niche. Recent evidence highlights syntaxin 7 (STX7), a Qa\u2010SNARE involved in endo\u2010lysosomal fusion, as a potential\n                    <jats:italic>Salmonella<\/jats:italic>\n                    target. BioID screening revealed STX7 interactions with SPI\u20102 effectors SifA and SopD2, suggesting a critical role in\n                    <jats:italic>Salmonella<\/jats:italic>\n                    pathogenesis. We investigated the role of STX7 in\n                    <jats:italic>Salmonella<\/jats:italic>\n                    \u2010containing vacuole (SCV) biogenesis and pathogenesis in macrophages and epithelial cells. Our findings indicate that STX7 levels and localization differ between these cell types during infection, reflecting the distinct survival strategies of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    . Live cell imaging showed that STX7 is recruited to SCVs at different infection stages, with significantly altered distribution in HeLa cells at the late stage of infection. STX7 knockdown resulted in reduced bacterial survival, which was rescued upon overexpression of STX7 in both HeLa and RAW264.7 cells, suggesting\n                    <jats:italic>Salmonella<\/jats:italic>\n                    hijacks STX7 to evade lysosomal fusion and secure nutrients for intracellular replication. These results underscore the essential role of STX7 in maintaining SCVs and facilitating\n                    <jats:italic>Salmonella<\/jats:italic>\n                    survival. Further, the temporal expression of STX7 adaptor\/binding partners in macrophages showed dynamic interactions with STX7 facilitating\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection and survival in host cells. Together, our study highlights STX7 as a critical host factor exploited by\n                    <jats:italic>Salmonella<\/jats:italic>\n                    , providing insights into the molecular mechanisms underlying its pathogenesis in macrophages and epithelial cells. These findings may inform strategies for targeting host\u2010pathogen interactions to combat\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1111\/tra.70010","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:29:11Z","timestamp":1748579351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>\n                      <i>Salmonella Typhimurium<\/i>\n                    <\/scp>\n                    Manipulates Syntaxin 7 to\u00a0Navigate Endo\u2010Lysosomal Trafficking in Host Cells"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8614-8015","authenticated-orcid":false,"given":"Rhea","family":"Vij","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, Department of Microbiology and Cell Biology Indian Institute of Science  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-9245","authenticated-orcid":false,"given":"Ritika","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, Department of Microbiology and Cell Biology Indian Institute of Science  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilash Vijay","family":"Nair","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, Department of Microbiology and Cell Biology Indian Institute of Science  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmol","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, Department of Microbiology and Cell Biology Indian Institute of Science  Bangalore Karnataka 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India"},{"name":"Adjunct Faculty, Indian Institute of Science Research and Education  Thiruvananthapuram Kerala 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