{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:44:08Z","timestamp":1792629848391,"version":"4.5.0"},"reference-count":216,"publisher":"Wiley","issue":"10-12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":60,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010713","name":"Indian Institute of Science Education and Research Bhopal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Traffic"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Copper is one of the essential micronutrients utilized as a cofactor in a wide variety of biochemical reactions of metabolic pathways, including mitochondrial respiration and innate immune response. Cellular concentration and distribution of copper is regulated by copper\u2010specific transporters, chaperones, metallothionein proteins and amino acids. Transcription of a major copper metallothionein,\n                    <jats:italic>CUP1<\/jats:italic>\n                    is epigenetically regulated in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Mutations in histones dysregulate cellular copper homeostasis due to abnormal epigenetic changes and cause diseases in humans, such as cancerous growth and neurological disorders. Low or higher cellular concentration of copper is associated with disorders such as Menkes and Wilson's disease, respectively. Higher concentrations of copper cause caspase\u2010independent cell death known as cuproptosis and haemolytic anemia. We highlighted the existing knowledge regarding the significance of epigenetics and cellular factors in the regulation of copper metabolism and copper\u2010regulated protein trafficking. We have also proposed a few future directions to explore the role of cellular pH dynamics, stoichiometry among metals, amino acids and protein metabolism, histone modifications, autophagy and mitochondrial respiration in regulating cellular copper metabolism. Altogether, we provide a comprehensive summary of cellular factors targeting copper metabolism for dissecting the underlying complex mechanism of copper dynamics in normal physiology and diseases.\n                  <\/jats:p>","DOI":"10.1111\/tra.70024","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:10:02Z","timestamp":1764547802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Copper Homeostasis at the Crossroads of Cellular Metabolism, Epigenetic Regulation and Protein Trafficking"],"prefix":"10.1111","volume":"26","author":[{"given":"Vandana","family":"Anjana","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smriti","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateeksha","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajshree","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santoshi","family":"Acharjee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranu","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugandh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumawat","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-7839","authenticated-orcid":false,"given":"Raghuvir Singh","family":"Tomar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research Bhopal (IISERB)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2318692121"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.864830"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1913"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111687"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-2647(83)90029-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05639-w"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01229-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00125-18"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1019153"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2311630121"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.711227"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02412-2"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13681"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.72"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-9476.82523"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2019.09.005"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986706776055742"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-012-9578-y"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03251-21"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103256"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfad005"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"issue":"9","key":"e_1_2_12_24_1","article-title":"Copper\u2010Induced Haemolytic Anaemia","volume":"8","author":"Carvalho J. A.","year":"2021","journal-title":"European Journal of Case Reports in Internal Medicine"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-010-0034-2"},{"issue":"3","key":"e_1_2_12_26_1","first-page":"4708","article-title":"Hemolytic Anemia as First Presentation of Wilson's Disease With Uncommon ATP7B Mutation","volume":"8","author":"Ye X. N.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70190-5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz8899"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.09.007"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S180087"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09910-4"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.10.001"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13276"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000203098.77573.39"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2200554"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2015.01.005"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx900338d"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-024-07025-x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15846"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.12.035"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-263"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1590"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00202A"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411437200"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00210-20"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj9889"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0632-2"},{"issue":"8","key":"e_1_2_12_48_1","article-title":"Epigenetics in Neurological and Psychiatric Disorders: A Comprehensive Review of Current Understanding and Future Perspectives","volume":"15","author":"Grezenko H.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2828"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01197-3"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2016.1231289"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12347"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.02.43"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01333-7"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0496"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13682"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2021.103183"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.030"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01154-9"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.08.003"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488166"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0151-6"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2022.03.037"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00736-4"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.11"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.309013.117"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.12.6953"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.10.012"},{"issue":"19","key":"e_1_2_12_69_1","first-page":"10007","article-title":"Cancer\u2010Associated Mutations of Histones H2B, H3.1 and H2A.Z.1 Affect the Structure and Stability of the Nucleosome","volume":"46","author":"Arimura Y.","year":"2018","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.22"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600120"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27867-4"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108154"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.108163"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102170"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba8740"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107314"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2020.03.001"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105435"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2010.00217.x"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00077-07"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.104639"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0481-4"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2019.11.007"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.08.004"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.670265"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R111.316406"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm0660"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06017-4"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05722-11"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101314"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.110806"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1897"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.08.077"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18390"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.08.080"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01592-4"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0707-9"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02192-0"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.11.001"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2024.127549"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.051"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.03.054"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.09.040"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00156"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1995.tb01503.x"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.6.1536"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02917420"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-016-1335-1"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.12.003"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.647099"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.649129"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2022.100408"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00567"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00876-0"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba8740"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi7347"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800055200"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1243629"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02071-0"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.117725"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00577"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-020-00264-y"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2007.00616.x"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.16.4774-4779.1999"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.02.011"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202547200"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(99)01638-8"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.470674"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000265"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.39.27590"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.190298"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.11.046"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404747200"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr040410w"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2024.07.005"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16544-7"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-74180-8_2"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06435-w"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.6.1633S"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01569-3"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.02.004"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160822"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200788119"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703397200"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313746200"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0375-3"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2009.12.020"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0MT00044B"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-014-9731-x"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1080\/10985549.2025.2569577"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.19.11101"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812808106"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.04.001"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105677"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2010.06.015"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06384"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.2"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202357910"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.008"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.12.017"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar7899"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041250"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9403"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-050511-102312"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002907200"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01679-y"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.02.013"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20180067"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.005"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3890"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-120220-085159"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00468-7"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2015.10.007"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06635-y"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05656-9"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702729104"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-092719-082622"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08911"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2018.51.5.053"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad754"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.07.013"},{"issue":"37","key":"e_1_2_12_183_1","first-page":"E7717","article-title":"Clipping of Arginine\u2010Methylated Histone Tails by JMJD5 and JMJD7","volume":"114","author":"Liu H.","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1534"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.10.4857"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.055"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.462531"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2053"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68283"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.002255"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005283"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2021.05.020"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi700395d"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26047"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49486-5"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc9207"},{"key":"e_1_2_12_197_1","article-title":"Zinc is Essential for the Copper Reductase Activity of Yeast Nucleosomes","author":"Vogelauer M.","year":"2023","journal-title":"bioRxiv"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01741-2"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-030409-143539"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47223-4"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-023-01487-x"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15082286"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1082691"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42025-8"},{"key":"e_1_2_12_205_1","first-page":"13","article-title":"Characterization of the Functional Effects of Ferredoxin 1 as a Cuproptosis Biomarker in Cancer","volume":"13","author":"Li X.","year":"2022","journal-title":"Frontiers in Genetics"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114163"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8195"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0277-3"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.993030"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56585-4"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr4004665"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-013-1550-9"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200730214757"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.18.6406-6416.2002"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12804"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.020438"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2010.00685.x"}],"container-title":["Traffic"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tra.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T07:54:27Z","timestamp":1766476467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tra.70024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":216,"journal-issue":{"issue":"10-12","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/tra.70024"],"URL":"https:\/\/doi.org\/10.1111\/tra.70024","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/TRA.70024\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.70024\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.70024\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.70024\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/TRA.70024\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1398-9219","1600-0854"],"issn-type":[{"value":"1398-9219","type":"print"},{"value":"1600-0854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70024"}}