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This complex mechanism involves a coordinated assembly of the scaffold protein clathrin and more than 50 other endocytic proteins at endocytic sites. Clathrin polymerises into sturdy supramolecular lattices, yet its assembly is highly dynamic and controlled by the DnaJ\/Hsc70 uncoating machinery. Although clathrin turnover at endocytic sites was proposed early on to allow membrane deformation to occur, more recent studies have started hinting at possible regulatory functions. 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