{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:24:39Z","timestamp":1770823479373,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T00:00:00Z","timestamp":1355184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse donor reactions can result in injury and decrease the likelihood of donor return. Reaction reports captured in the blood center's database provide an incomplete picture of reaction rates and risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We performed an anonymous survey, mailed to 40,000 donors in 2008, including questions about symptoms, height, weight, sex, and donation status. Reaction rates were compared to those recorded in our database. Possible risk factors were assessed for various reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The response rate was 45.5%. A total of 32% of first\u2010time and 14% of repeat donors reported having any adverse symptom, most frequently bruising (84.9 per 1000 donors) or feeling faint or weak (66.2 per 1000). Faint reactions were two to eight times higher than reported in our database, although direct comparison was difficult. Younger age, female sex, and first\u2010time donation status were risk factors for systemic and arm symptoms. In females, low estimated blood volume (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) was a risk factor for systemic symptoms. Only 51% of donors who consulted an outside physician also called <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anadian <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>lood <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ervices. A total of 10% of first\u2010time donors with reactions found adverse effects information inadequate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study allowed us to collect more information about adverse reactions, including minor symptoms and delayed reactions. Based on our findings of the risk factors and frequency of adverse reactions, we are implementing more stringent <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> criteria for younger donors and providing more detailed information to donors about possible adverse effects and their management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12011","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T11:14:16Z","timestamp":1355224456000},"page":"1979-1984","source":"Crossref","is-referenced-by-count":27,"title":["Frequency and risk factors for donor reactions in an anonymous blood donor survey"],"prefix":"10.1111","volume":"53","author":[{"given":"Mindy","family":"Goldman","sequence":"first","affiliation":[{"name":"Medical, Scientific and Research Affairs Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Osmond","sequence":"additional","affiliation":[{"name":"Medical, Scientific and Research Affairs Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2010Long","family":"Yi","sequence":"additional","affiliation":[{"name":"Medical, Scientific and Research Affairs Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keltie","family":"Cameron\u2010Choi","sequence":"additional","affiliation":[{"name":"Medical, Scientific and Research Affairs Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Medical, Scientific and Research Affairs Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01811.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03216.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00905.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2003.08.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.19.2279"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01745.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02397.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01494.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03143.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03074.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2012.01559.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00368.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03078.x"},{"key":"e_1_2_7_15_1","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler SB","year":"1962","journal-title":"Surgery"},{"key":"e_1_2_7_16_1","volume-title":"Categorical data analysis","author":"Agresti A","year":"1990"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04105.x"},{"key":"e_1_2_7_18_1","first-page":"85","volume-title":"Blood donor health and safety","author":"Newman B","year":"2009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03202.x"},{"key":"e_1_2_7_20_1","volume-title":"Association Bulletin 08\u201004, Appendix 1. Recommendations to minimize the risk of reactions and injuries among adolescent blood donors","author":"Eder A","year":"2008"},{"key":"e_1_2_7_21_1","volume-title":"Standards for blood banks and transfusion services","author":"American Association of Blood Banks","year":"2012"},{"key":"e_1_2_7_22_1","unstructured":"American Association of Blood Banks.Biovigilance.2012. [cited 2012 Oct 16]. 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