{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T18:02:38Z","timestamp":1751652158227},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T00:00:00Z","timestamp":1356307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Background<\/jats:title>Platelet (PLT<\/jats:styled-content>) support is critical to the care of patients with thrombocytopenia, but allogeneic transfusions carry risk. Pathogen reduction mitigates some transfusion risks, but effects on PLT<\/jats:styled-content> function remain a concern. This clinical pilot study assessed the effect of pathogen reduction technology with riboflavin plus ultraviolet light using thrombelastography (TEG<\/jats:styled-content>).<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>This prospective, randomized, crossover study compared Mirasol\u2010treated (MIR<\/jats:styled-content>) and standard reference (REF<\/jats:styled-content>) PLT transfusions. PLT<\/jats:styled-content> counts and TEG<\/jats:styled-content> measurements were taken at pretransfusion and 1\u2010 and 24\u2010hour\u2010posttransfusion time points. The primary outcome measure was the pretransfusion to 1\u2010hour\u2010posttransfusion change in maximum amplitude (\u0394MA<\/jats:styled-content>1hr<\/jats:sub>). Secondary endpoints included \u0394MA<\/jats:styled-content> among other time points, relative MA<\/jats:styled-content>, and the PLT<\/jats:styled-content> count\u2013MA<\/jats:styled-content> correlation.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 16 enrolled patients, one withdrew before study treatment and three did not require two transfusions, leaving 12 patients in the efficacy analyses (seven MIR\u2010REF<\/jats:styled-content>, five REF\u2010MIR<\/jats:styled-content>). \u0394MA<\/jats:styled-content>1hr<\/jats:sub> (mean\u2009\u00b1\u2009SD<\/jats:styled-content>) was 10.60\u2009\u00b1\u20096.47\u2009mm for MIR<\/jats:styled-content> and 14.33\u2009\u00b1\u20095.38\u2009mm for REF<\/jats:styled-content> (p\u2009=\u20090.20, n\u2009=\u200910). \u0394MA<\/jats:styled-content>24hr<\/jats:sub> was 9.49\u2009\u00b1\u20097.94 for MIR<\/jats:styled-content> and 7.13\u2009\u00b1\u20093.08 for REF<\/jats:styled-content> (p\u2009=\u20090.38, n\u2009=\u20099); \u0394MA<\/jats:styled-content>24hr\u20101hr<\/jats:sub> was \u22121.11\u2009\u00b1\u20092.95 for MIR<\/jats:styled-content> and \u22127.20\u2009\u00b1\u20094.81 for REF<\/jats:styled-content> (p\u2009=\u20090.016, n\u2009=\u20098). MA<\/jats:styled-content> values for MIR<\/jats:styled-content> and REF<\/jats:styled-content> correlated with the log of PLT count (rMIR<\/jats:sub><\/jats:styled-content>\u2009=\u20090.6901, rREF<\/jats:sub><\/jats:styled-content>\u2009=\u20090.7399).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>TEG<\/jats:styled-content> is sensitive to changes in hemostatic function resulting from a single PLT transfusion. MIR<\/jats:styled-content> and REF<\/jats:styled-content> provided similar increments in hemostatic function in the immediate posttransfusion period and at 24 hours. A significant difference detected for \u0394MA<\/jats:styled-content>24hr\u20101hr<\/jats:sub> suggests different PLT<\/jats:styled-content> clearance mechanisms. The relationship of these variables to clinically meaningful outcomes, for example, bleeding events or transfusion requirements, has yet to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12055","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T11:23:14Z","timestamp":1356348194000},"page":"2043-2052","source":"Crossref","is-referenced-by-count":17,"title":["A pilot study to assess the hemostatic function of pathogen\u2010reduced platelets in patients with thrombocytopenia"],"prefix":"10.1111","volume":"53","author":[{"given":"P\u00e4r I.","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Section of Transfusion Medicine Copenhagen Denmark"},{"name":"Department of Hematology University of Copenhagen Copenhagen Denmark"},{"name":"Terumo BCT Lakewood Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Catrine","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Section of Transfusion Medicine Copenhagen Denmark"},{"name":"Department of Hematology University of Copenhagen Copenhagen Denmark"},{"name":"Terumo BCT Lakewood Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Section of Transfusion Medicine Copenhagen Denmark"},{"name":"Department of Hematology University of Copenhagen Copenhagen Denmark"},{"name":"Terumo BCT Lakewood Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisse R.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Section of Transfusion Medicine Copenhagen Denmark"},{"name":"Department of Hematology University of Copenhagen Copenhagen Denmark"},{"name":"Terumo BCT Lakewood 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