{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:58:10Z","timestamp":1772002690906,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Background<\/jats:title>Immune\u2010mediated hemolysis is not included in the list of adverse reactions related to contrast medium (CM<\/jats:styled-content>). Here, we report on a patient who developed immune hemolytic anemia (IHA<\/jats:styled-content>) related to iomeprol, a nonionic CM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>A 34\u2010year\u2010old female patient developed massive hemolysis during infusion of 50\u2009mL<\/jats:styled-content> of iomeprol. Serologic studies were performed using standard techniques.<\/jats:p><\/jats:sec>Results<\/jats:title>Before hemolysis, the patient's serum was weakly positive with e+ red blood cells (RBCs<\/jats:styled-content>; autoanti\u2010e) and the direct antiglobulin test (DAT<\/jats:styled-content>) was negative. After hemolysis, the patient's serum samples became significantly reactive with e\u2013 RBCs<\/jats:styled-content> in the presence of iomeprol but not in the presence of two other similar CM<\/jats:styled-content>. The DAT<\/jats:styled-content> became strongly positive only with anti\u2010C3d<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Initially, an allergic reaction was suggested, and as the hemolysis became obvious, a toxic hemolysis was suspected. However, serologic reexamination revealed an iomeprol\u2010dependent antibody. IHA<\/jats:styled-content> related to CM<\/jats:styled-content> has yet only been described in one patient in 1991. The hemolysis in that patient was related to Isopaque, an older ionic CM<\/jats:styled-content>. Here, we describe an additional patient and recommend that CM<\/jats:styled-content> should be considered as a rare risk in the development of IHA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12089","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T16:40:19Z","timestamp":1359045619000},"page":"2141-2144","source":"Crossref","is-referenced-by-count":9,"title":["Intravascular immune hemolysis caused by the contrast medium iomeprol"],"prefix":"10.1111","volume":"53","author":[{"given":"Beate","family":"Mayer","sequence":"first","affiliation":[{"name":"Institute for Transfusion Medicine Charit\u00e9\u2013University Medicine Berlin Berlin Germany"},{"name":"Institute for Clinical Transfusion Medicine and Cellular Therapy, and Clinic for General, Visceral and Transplantation Surgery University Medical Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Leo","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Charit\u00e9\u2013University Medicine Berlin Berlin Germany"},{"name":"Institute for Clinical Transfusion Medicine and Cellular Therapy, and Clinic for General, Visceral and Transplantation Surgery University Medical Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Herziger","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Charit\u00e9\u2013University Medicine Berlin Berlin Germany"},{"name":"Institute for Clinical Transfusion Medicine and Cellular Therapy, and Clinic for General, Visceral and Transplantation Surgery University Medical Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Houben","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Charit\u00e9\u2013University Medicine Berlin Berlin Germany"},{"name":"Institute for Clinical Transfusion Medicine and Cellular Therapy, and Clinic for General, Visceral and Transplantation Surgery University Medical Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schemmer","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Charit\u00e9\u2013University Medicine Berlin Berlin Germany"},{"name":"Institute for Clinical Transfusion Medicine and Cellular Therapy, and Clinic for General, Visceral and Transplantation Surgery University Medical Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulgabar","family":"Salama","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Charit\u00e9\u2013University Medicine Berlin Berlin Germany"},{"name":"Institute for Clinical Transfusion Medicine and Cellular Therapy, and Clinic for General, Visceral and Transplantation Surgery University Medical Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059050-00013"},{"key":"e_1_2_8_3_1","first-page":"183","article-title":"Are nonionic contrast media identical in their tolerability? 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