{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:00:52Z","timestamp":1791320452373,"version":"4.3.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Background<\/jats:title>\n \n Hyperhemolysis syndrome is a serious transfusion reaction mostly reported in association with sickle cell disease, characterized by destruction of both donor and host red blood cells (\n RBCs<\/jats:styled-content>\n ) by an unknown mechanism.\n <\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n \n A 21\u2010year\u2010old man with sickle cell disease and multiple prior transfusions received two phenotype\u2010matched, compatible\n RBC<\/jats:styled-content>\n units during a brief admission for pain crisis. He developed rapid\u2010onset progressive anemia and hemoglobinuria. Methylprednisolone, erythropoietin, and rituximab were administered. Fifteen days posttransfusion the hemoglobin (\n Hb<\/jats:styled-content>\n ) concentration decreased to 3.1\u2009g\/\n dL<\/jats:styled-content>\n , with evidence of severe congestive heart failure. No new antibodies were identified. It was felt that his heart failure would not improve without increasing oxygen\u2010carrying capacity. A combination of volume overload, anemia, and hemolysis prompted a novel isovolemic procedure to increase\n Hb<\/jats:styled-content>\n level without removing his own\n RBCs<\/jats:styled-content>\n or causing fluid overload. A cell separator was used operating on the plasma\u2010exchange program, with three cross\u2010match\u2013compatible, washed\n RBC<\/jats:styled-content>\n units as the replacement fluid. After the procedure, there was no evidence of hemolysis. Over the following 6 days, the congestive heart failure resolved, the\n Hb<\/jats:styled-content>\n concentration increased to 7.5\u2009g\/\n dL<\/jats:styled-content>\n , and the patient fully recovered. He had a similar event 3 years previously.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Plasma\u2010to\u2010\n RBC<\/jats:styled-content>\n replacement may be beneficial for selected patients with life\u2010threatening anemia. This intervention provides immediate improvement in oxygen\u2010carrying capacity, conserving the patient's own\n RBCs<\/jats:styled-content>\n , while avoiding fluid overload. Although blood transfusion may precipitate further hemolysis, this case report describes successful plasma\u2010to\u2010RBC exchange transfusion with concurrent supportive care to offset hemolysis, including corticosteroid, intravenous immunoglobulin, and rituximab.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.12258","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:23:46Z","timestamp":1369182226000},"page":"384-388","source":"Crossref","is-referenced-by-count":36,"title":["Successful treatment of recurrent hyperhemolysis syndrome with immunosuppression and plasma\u2010to\u2010red blood cell exchange transfusion"],"prefix":"10.1111","volume":"54","author":[{"given":"Erik J.","family":"Uhlmann","sequence":"first","affiliation":[{"name":"Transfusion Medicine and Pheresis Unit Beth Israel Deaconess Medical Center Boston Massachusetts"},{"name":"Departments of Hematology, Oncology and Bone Marrow Transplant St Louis Children's Hospital St Louis Missouri"},{"name":"Departments of Pathology and Medicine Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Pheresis Unit Beth Israel Deaconess Medical Center Boston Massachusetts"},{"name":"Departments of Hematology, Oncology and Bone Marrow Transplant St Louis Children's Hospital St Louis Missouri"},{"name":"Departments of Pathology and Medicine Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence T.","family":"Goodnough","sequence":"additional","affiliation":[{"name":"Transfusion Medicine and Pheresis Unit Beth Israel Deaconess Medical Center Boston Massachusetts"},{"name":"Departments of Hematology, Oncology and Bone Marrow Transplant St Louis Children's Hospital St Louis Missouri"},{"name":"Departments of Pathology and Medicine Stanford University Medical Center Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01693.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-2-231"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.371098016453.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.e661"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265334.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265337.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265338.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.371098016454.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41030323.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00608.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.09.2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01351.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.257"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1995.tb00373.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21578"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12074"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.12258","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.12258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T12:33:04Z","timestamp":1696163584000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.12258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/trf.12258"],"URL":"https:\/\/doi.org\/10.1111\/trf.12258","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,21]]}}}