{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:56:11Z","timestamp":1780322171928,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,30]],"date-time":"2013-06-30T00:00:00Z","timestamp":1372550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Chronic granulomatous disease (<jats:styled-content style=\"fixed-case\">CGD<\/jats:styled-content>) is a rare inherited primary immunodeficiency that affects phagocytic cells. <jats:styled-content style=\"fixed-case\">CGD<\/jats:styled-content> patients are susceptible to fungal infections, especially <jats:italic>Aspergillus<\/jats:italic> infections. The management of life\u2010threatening <jats:italic>Aspergillus<\/jats:italic> infections in <jats:styled-content style=\"fixed-case\">CGD<\/jats:styled-content> is particularly difficult because some infections cannot be eradicated with standard antifungal treatments and, hence, result in death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report:<\/jats:title><jats:p>A 2\u2010week\u2010old girl developed invasive pulmonary aspergillosis, which rapidly progressed to respiratory failure. Liposomal amphotericin B, micafungin, and voriconazole were not effective. At the age of 2 months, she was diagnosed with p67phox\u2010deficient <jats:styled-content style=\"fixed-case\">CGD<\/jats:styled-content>. In addition to antifungal treatment, the patient received 21 granulocyte transfusions (<jats:styled-content style=\"fixed-case\">GTX<\/jats:styled-content>), which were obtained from 300\u2010 or 400\u2010<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> whole blood samples from healthy random donors who were not treated with granulocyte\u2013colony\u2010stimulating factor or dexamethasone. The median neutrophil count of the <jats:styled-content style=\"fixed-case\">GTX<\/jats:styled-content> was 1.88\u2009\u00d7\u200910<jats:sup>8<\/jats:sup>\/kg body weight. Rituximab was administered to reduce alloimmunization to human leukocyte antigens (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) after the eighth <jats:styled-content style=\"fixed-case\">GTX<\/jats:styled-content>, resulting in their absence of anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> before and after cord blood transplantation (<jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>). A marked improvement in her invasive pulmonary aspergillosis was achieved, although the first <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> was rejected. Complete hematopoietic recovery was obtained after the second <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Repeated <jats:styled-content style=\"fixed-case\">GTX<\/jats:styled-content> containing relatively low doses of neutrophils might be able to control severe <jats:italic>Aspergillus<\/jats:italic> infections in infants with <jats:styled-content style=\"fixed-case\">CGD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12325","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T04:06:56Z","timestamp":1372651616000},"page":"516-521","source":"Crossref","is-referenced-by-count":17,"title":["Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis"],"prefix":"10.1111","volume":"54","author":[{"given":"Tomonari","family":"Shigemura","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yozo","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimoto","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sakashita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Shiohara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion Medicine Cell Processing Center Shinshu University Hospital"},{"name":"Department of Infection and Host Defense Shinshu University, Graduate School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Hematology, Oncology, and Immunology Nagano Children's Hospital  Azumino Japan"},{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"},{"name":"Division of Transfusion 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