{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:17:39Z","timestamp":1791310659627,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Studies have shown heterogeneity in red blood cell transfusion practices. Although plasma transfusion is common in intensive care, there are no data on plasma transfusion practices in pediatric critical care units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A scenario\u2010based survey was sent to 718 pediatric critical care physicians working in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>urope, <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merica, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia, and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand. Respondents were asked to report their decisions regarding plasma transfusion practice with respect to four scenarios: pneumonia, septic shock, traumatic brain injury (TBI), and postoperative care after a Tetralogy of Fallot correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The response rate was 187 of 718 (26%); half of the responders worked in <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merica. The proportion of physicians who transfused plasma to nonbleeding patients, solely based on abnormal international normalized ratio (<jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>), varied from 66% for pneumonia to 84% for TBI (p\u2009&lt;\u20090.001). In such nonbleeding patients, the median <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> threshold that would trigger plasma transfusion was 2.5 for pneumonia and septic shock patients and 2.0 for TBI and the cardiac postoperative patients (p\u2009&lt;\u20090.001). Minor bleeding, minor surgery, insertion of a femoral line, hypotension, abnormal activated partial thromboplastin time, thrombocytopenia, and anemia levels were important determinants of plasma transfusion, whereas none of the respondents' demographic characteristics were important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than two\u2010thirds of responding pediatric critical care physicians prescribe plasma transfusions for nonbleeding critically ill children. Additionally, there is a significant variation in transfusion practice patterns with respect to plasma transfusion thresholds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12393","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T11:20:57Z","timestamp":1377602457000},"page":"1125-1132","source":"Crossref","is-referenced-by-count":14,"title":["International survey on plasma transfusion practices in critically ill children"],"prefix":"10.1111","volume":"54","author":[{"given":"Oliver","family":"Karam","sequence":"first","affiliation":[{"name":"Pediatric Critical Care Unit Geneva University Hospital  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Tucci","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit Sainte\u2010Justine Hospital, Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit Sainte\u2010Justine Hospital, Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Rimensberger","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Unit Geneva University Hospital  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Critical Care Trials Group and of the Pediatric Acute Lung Injury and Sepsis Investigator Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1539","article-title":"Prospective audit of the use of fresh\u2010frozen plasma, based on Canadian Medical Association transfusion guidelines","volume":"166","author":"Luk C","year":"2002","journal-title":"CMAJ"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.08.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12009"},{"key":"e_1_2_8_5_1","unstructured":"Report of the US Department of Health and Human Services.The 2009 National Blood Collection and Utilization Survey Report. 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