{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:10:21Z","timestamp":1773234621560,"version":"3.50.1"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T00:00:00Z","timestamp":1377561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Background<\/jats:title>Blood transfusions are common during hematopoietic stem cell transplantation (HSCT<\/jats:styled-content>) and may contribute to lung injury.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>This study examined the associations between red blood cell (RBC<\/jats:styled-content>) and platelet (PLT<\/jats:styled-content>) transfusions and idiopathic pneumonia syndrome (IPS<\/jats:styled-content>) among 914 individuals who underwent myeloablative allogeneic HSCT<\/jats:styled-content> between 1997 and 2001. Patients received allogeneic blood transfusions at their physicians' discretion. RBCs<\/jats:styled-content>, PLTs<\/jats:styled-content>, and a composite of \u201cother\u201d transfusions were quantified as the sum of units received each 7\u2010day period from 6 days before transplant until IPS<\/jats:styled-content> onset, death, or P<\/jats:styled-content>osttransplant D<\/jats:styled-content>ay 120. RBC<\/jats:styled-content> and PLT<\/jats:styled-content> transfusions were modeled as separate time\u2010varying exposures in proportional hazards models adjusted for IPS<\/jats:styled-content> risk factors (age, baseline disease, irradiation dose) and other transfusions. Timing of PLT<\/jats:styled-content> transfusion relative to myeloid engraftment and PLT ABO<\/jats:styled-content> blood group (match vs. mismatch) were included as potential interaction terms.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients received a median of 9 PLT<\/jats:styled-content> and 10 RBC<\/jats:styled-content> units. There were 77 IPS<\/jats:styled-content> cases (8.4%). Each additional PLT<\/jats:styled-content> unit transfused in the prior week was associated with 16% higher IPS<\/jats:styled-content> risk (hazard ratio, 1.16; 95% confidence interval, 1.09\u20101.23; p\u2009<\u20090.001). Recent RBC and PLT transfusions were each significantly associated with greater risk of IPS<\/jats:styled-content> when examined without the other; only PLT<\/jats:styled-content> transfusions retained significance when both exposures were included in the model. The PLT<\/jats:styled-content> association was not modified by engraftment or ABO<\/jats:styled-content> mismatch.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>PLT<\/jats:styled-content> transfusions are associated with greater risk of IPS<\/jats:styled-content> after myeloablative HSCT<\/jats:styled-content>. RBC<\/jats:styled-content>s may also contribute; however, these findings need confirmation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12396","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T11:22:42Z","timestamp":1377602562000},"page":"1071-1080","source":"Crossref","is-referenced-by-count":29,"title":["The association between red blood cell and platelet transfusion and subsequently developing idiopathic pneumonia syndrome after hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"54","author":[{"given":"Lisa K.","family":"Vande Vusse","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of Washington Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Madtes","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine University of Washington Washington"},{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"Guthrie","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry B.","family":"Gernsheimer","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Washington Washington"},{"name":"Research Institute Puget Sound Blood Center Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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