{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:29:42Z","timestamp":1787956182102,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Background<\/jats:title>Insulin\u2010like growth factor 1 (IGF<\/jats:styled-content>\u20101) and IGF<\/jats:styled-content>\u2010binding protein\u20103 (IGFBP\u20103) play a main role in the pathogenesis of retinopathy of prematurity (ROP<\/jats:styled-content>). Fresh\u2010frozen plasma (FFP<\/jats:styled-content>) from adult donors may be an actual source of IGF\u20101<\/jats:styled-content> and IGFBP<\/jats:styled-content>\u20103 because it contains higher concentrations. The objective was to evaluate whether FFP<\/jats:styled-content> transfusions can decrease the occurrence of ROP<\/jats:styled-content> in a cohort of preterm infants.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>We retrospectively analyzed data from 218 infants with gestational age\u2009of less than\u200929 weeks who either received FFP<\/jats:styled-content> or did not and correlated this procedure to the development of any grade of ROP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Logistic regression analysis demonstrated that two or more transfusions of FFP<\/jats:styled-content> was effective in decreasing the risk of development of any grade of ROP<\/jats:styled-content> (relative risk, 0.46; 95% confidence interval, 0.23\u20100.93). Other factors that affected the risk of ROP<\/jats:styled-content> were gestational age, birthweight, antenatal steroid treatment, FiO<\/jats:styled-content>2<\/jats:sub>\u2009of at least 0.40, mechanical ventilation, and sepsis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We found that two or more transfusions of FFP<\/jats:styled-content> in the first week of life decrease the risk of developing any grade of ROP<\/jats:styled-content> in preterm infants with gestational age\u2009of less than\u200929 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12432","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:32:48Z","timestamp":1381545168000},"page":"1002-1007","source":"Crossref","is-referenced-by-count":17,"title":["Early fresh\u2010frozen plasma transfusion decreases the risk of retinopathy of prematurity"],"prefix":"10.1111","volume":"54","author":[{"given":"Carlo","family":"Dani","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Poggi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Bresci","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuri","family":"Corsini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Frosini","sequence":"additional","affiliation":[{"name":"Department of Oto\u2010Neuro\u2010Ophthalmological Surgical Sciences University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200105000-00003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.09.042"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20530"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20001201)62:5<700::AID-JNR9>3.0.CO;2-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.5.1016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101113998"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702031104"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1293"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02328.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.5.1651.1651"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60071-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0249"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80189-5"},{"key":"e_1_2_8_18_1","first-page":"1669","article-title":"The International Classification of Retinopathy of Prematurity revisited","volume":"124","author":"International Committee for the Classification of Retinopathy of Prematurity","year":"2005","journal-title":"Arch 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