{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:29:57Z","timestamp":1767896997364,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T00:00:00Z","timestamp":1382918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Background<\/jats:title>Graft\u2010versus\u2010host disease (GVHD<\/jats:styled-content>) is a major cause of morbimortality after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT<\/jats:styled-content>). Minor ABO<\/jats:styled-content> incompatibility has been associated with an increased risk of GVHD<\/jats:styled-content>. We analyzed the impact of ABO<\/jats:styled-content> matching on patient outcome after peripheral blood, reduced\u2010intensity allo\u2010HSCT<\/jats:styled-content> in an outpatient setting, and its relationship with GVHD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>Data of 121 patients were included. All patients received allo\u2010HSCT<\/jats:styled-content> from HLA<\/jats:styled-content>\u2010identical siblings as outpatients using a reduced\u2010intensity conditioning regimen. Influence of ABO<\/jats:styled-content> matching as a risk factor for the development of GVHD<\/jats:styled-content> and survival was analyzed using logistic regression and C<\/jats:styled-content>ox proportional hazards regression, respectively.<\/jats:p><\/jats:sec>Results<\/jats:title>Median age was 36 years (range, 1\u201071 years); 88 patients were ABO<\/jats:styled-content> identical: 13 presented major mismatch and 20 minor mismatch, with an ABO<\/jats:styled-content> incompatibility rate of 27.3%. The median follow\u2010up period was 54 months (range, 0.3\u2010120 months). Minor ABO<\/jats:styled-content> incompatibility patients presented the highest rate of acute GVHD<\/jats:styled-content> (aGVHD; 25%), in comparison with ABO<\/jats:styled-content>\u2010identical (20.5%) and major ABO<\/jats:styled-content> incompatibility patients (15.4%; p\u2009=\u20090.79). The highest incidence of chronic GVHD<\/jats:styled-content> (cGVHD<\/jats:styled-content>) occurred in the context of minor ABO<\/jats:styled-content> incompatibility (35%), in contrast to ABO<\/jats:styled-content>\u2010identical (30.8%) and major ABO<\/jats:styled-content> incompatibility (15.4%). Survival was higher for patients in the minor ABO<\/jats:styled-content> mismatch group; however, there was no significant correlation between ABO<\/jats:styled-content> matching status and survival (p\u2009=\u20090.45).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Using this type of peripheral blood stem cell transplantation, minor ABO<\/jats:styled-content>\u2010mismatched allo\u2010HSCT<\/jats:styled-content> was associated with a higher incidence of aGVHD<\/jats:styled-content> and cGVHD<\/jats:styled-content> and with increased survival, albeit with no significance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12466","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T09:34:14Z","timestamp":1382952854000},"page":"1269-1277","source":"Crossref","is-referenced-by-count":18,"title":["Allogeneic peripheral blood stem cell transplantation using reduced\u2010intensity conditioning in an outpatient setting in ABO<\/scp>\u2010incompatible patients: are survival and graft\u2010versus\u2010host disease different?"],"prefix":"10.1111","volume":"54","author":[{"given":"Cesar Homero","family":"Guti\u00e9rrez\u2010Aguirre","sequence":"first","affiliation":[{"name":"Hematology Service, Internal Medicine Department Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"G\u00f3mez\u2010De\u2010Le\u00f3n","sequence":"additional","affiliation":[{"name":"Hematology Service, Internal Medicine Department Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Alatorre\u2010Ricardo","sequence":"additional","affiliation":[{"name":"Hematology Service, Internal Medicine Department Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Graciela","family":"Cant\u00fa\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hematology Service, Internal Medicine Department Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Gonz\u00e1lez\u2010Llano","sequence":"additional","affiliation":[{"name":"Hematology Service, Internal Medicine Department Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez,\u201d Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 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