{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:53:17Z","timestamp":1791597197431,"version":"4.3.4"},"reference-count":68,"publisher":"Wiley","issue":"3pt2","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\"><jats:styled-content>R<\/jats:styled-content><\/jats:styled-content>ecipient <jats:styled-content style=\"fixed-case\"><jats:styled-content>E<\/jats:styled-content><\/jats:styled-content>pidemiology and <jats:styled-content style=\"fixed-case\"><jats:styled-content>D<\/jats:styled-content><\/jats:styled-content>onor <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>valuation <jats:styled-content style=\"fixed-case\"><jats:styled-content>S<\/jats:styled-content><\/jats:styled-content>tudy\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">REDS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) is a 7\u2010year multicenter transfusion safety research initiative launched in 2011 by the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ung, and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>lood <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nstitute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>The domestic component involves four blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct programs in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>razil, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina, and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>outh <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>frica, which involve <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> and in\u2010country investigators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">REDS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> is using two major methods to address key research priorities in blood banking and transfusion medicine. First, there will be numerous analyses of large \u201ccore\u201d databases; the international programs have each constructed a donor and donation database while the domestic program has established a detailed research database that links data from blood donors and their donations, the components made from these donations, and data extracts from the electronic medical records of the recipients of these components. Second, there are more than 25 focused research protocols involving transfusion recipients, blood donors, or both that either are in progress or are scheduled to begin within the next 3 years. Areas of study include transfusion epidemiology and blood utilization, transfusion outcomes, noninfectious transfusion risks, human immunodeficiency virus\u2013related safety issues (particularly in the international programs), emerging infectious agents, blood component quality, donor health and safety, and other donor issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is intended that <jats:styled-content style=\"fixed-case\">REDS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> serve as an impetus for more widespread recipient and linked donor\u2013recipient research in the <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tates as well as to help assure a safe and available blood supply in the United States and in international locations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12468","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T04:26:45Z","timestamp":1383625605000},"page":"942-955","source":"Crossref","is-referenced-by-count":92,"title":["The <scp>N<\/scp>ational <scp>H<\/scp>eart, <scp>L<\/scp>ung, and <scp>B<\/scp>lood <scp>I<\/scp>nstitute <scp>R<\/scp>ecipient <scp>E<\/scp>pidemiology and <scp>D<\/scp>onor <scp>E<\/scp>valuation <scp>S<\/scp>tudy (<scp>REDS<\/scp>\u2010<scp>III<\/scp>): a research program striving to improve blood donor and transfusion recipient outcomes"],"prefix":"10.1111","volume":"54","author":[{"given":"Steven","family":"Kleinman","sequence":"first","affiliation":[{"name":"Department of Pathology University of British Columbia  Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Busch","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute  San 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Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone A.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Cellular Therapeutics Branch National Heart, Lung, and Blood Institute National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study 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