{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:19:33Z","timestamp":1790813973291,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Risks and benefits of increasing placental transfusion in extremely preterm infants (extremely low birthweight [<jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content>], &lt;1000\u2009g) are ill defined. We performed a meta\u2010analysis to compare long\u2010 and short\u2010term outcomes of <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants in trials of enhanced placental transfusion regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We conducted a meta\u2010analysis of randomized controlled trials (RCTs) of delayed umbilical cord clamping or umbilical cord milking in compliance with <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollaborative guidelines for systematic reviews. We searched multiple databases for medical literature up to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012. Inclusion criteria were preterm infants less than 30 weeks and less than 1000\u2009g birthweight, randomly assigned to enhanced placental transfusion (either delayed cord clamping or cord milking) versus immediate cord clamping. The primary outcome was standardized neurodevelopmental outcome at 18 to 24 months corrected age using a standardized scale. Several short\u2010term outcomes were also evaluated as secondary variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 19 studies of which 10 studies could be included (n\u2009=\u2009199). Three reported neurodevelopmental outcomes, none of which showed significant rates of disability. Two reported these at 18 to 24 months (n\u2009=\u200942) but used different scales preventing pooling. Short\u2010term benefits of enhanced placental strategies included better blood pressure and hemoglobin on admission, along with reduced blood transfusions, a trend to reduced intraventricular hemorrhage, and episodes of late\u2010onset sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Strategies to enhance placental transfusion may improve short\u2010term outcomes of <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants. However, paucity of data on neurodevelopmental outcomes and safety concerns tempers enthusiasm for these interventions. Appropriately designed RCTs to assess short\u2010term and long\u2010term outcomes are needed in <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12469","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T10:18:58Z","timestamp":1383733138000},"page":"1192-1198","source":"Crossref","is-referenced-by-count":76,"title":["Effects of placental transfusion in extremely low birthweight infants: meta\u2010analysis of long\u2010 and short\u2010term outcomes"],"prefix":"10.1111","volume":"54","author":[{"given":"Sarvin","family":"Ghavam","sequence":"first","affiliation":[{"name":"Neonatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dushyant","family":"Batra","sequence":"additional","affiliation":[{"name":"Neonatology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Mercer","sequence":"additional","affiliation":[{"name":"College of Nursing University of Rhode Island  Kingston Rhode Island"},{"name":"Alpert  Medical School of Brown University Women and Infants' Hospital of Rhode Island USA  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Kugelman","sequence":"additional","affiliation":[{"name":"Department of Neonatology Bnai\u2010Zion Medical Center B&amp;R Rappaport Faculty of Medicine Technion  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeharu","family":"Hosono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Oh","sequence":"additional","affiliation":[{"name":"Alpert  Medical School of Brown University Women and Infants' Hospital of Rhode Island USA  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Rabe","sequence":"additional","affiliation":[{"name":"Neonatology Brighton and Sussex University Hospital  Brighton Sussex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haresh","family":"Kirpalani","sequence":"additional","affiliation":[{"name":"Neonatology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Clinical Epidemiology and Biostatistics McMaster University Medical School  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.074534"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.11.1241"},{"key":"e_1_2_8_4_1","unstructured":"AbalosE.Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes: RHL commentary. 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