{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:23:56Z","timestamp":1789025036589,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,4]],"date-time":"2013-11-04T00:00:00Z","timestamp":1383523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Antibodies to the high\u2010incidence red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) antigen <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an (<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>angereis) are typically immunoglobulin\u2009<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> and have been shown to fix complement and cause hemolysis of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an antigen\u2013positive <jats:styled-content style=\"fixed-case\">RBCs<\/jats:styled-content>. Only three cases of hemolytic disease of the fetus and newborn (<jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>) have been reported involving anti\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an and all have been characterized as \u201cmild.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 26\u2010year\u2010old <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ispanic female presented in her fifth pregnancy for routine obstetric care. Due to progressively rising anti\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an titers, middle cerebral artery (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>opplers were performed. At 32 weeks of gestation, the antibody titer had reached 128; the <jats:styled-content style=\"fixed-case\">MCA D<\/jats:styled-content>oppler indicated that fetal anemia was severe. An intrauterine transfusion with <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an antigen\u2013negative <jats:styled-content style=\"fixed-case\">RBCs<\/jats:styled-content> was performed and a viable infant was delivered 25 days later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Three cases of <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content> associated with anti\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an have been previously reported. While these cases have been associated with somewhat variable serologic findings, none have resulted in fetal demise or severe symptomatology requiring pre\u2010 or postnatal intervention other than routine phototherapy. The current report, however, suggests that in some instances anti\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an can result in a more severe form of <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content> requiring more aggressive prenatal therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In spite of previous case reports suggesting that anti\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>an is associated with relatively mild <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>, this case suggests that in some instances, this antibody can cause severe <jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content> requiring prenatal intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12473","type":"journal-article","created":{"date-parts":[[2013,11,5]],"date-time":"2013-11-05T04:26:59Z","timestamp":1383625619000},"page":"1317-1320","source":"Crossref","is-referenced-by-count":5,"title":["Hemolytic disease of the fetus and newborn caused by anti\u2010<scp>L<\/scp>an"],"prefix":"10.1111","volume":"54","author":[{"given":"Sarah","family":"Brooks","sequence":"first","affiliation":[{"name":"Pathology and Laboratory Medicine Medical University of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry E.","family":"Squires","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine Medical University of South Carolina  Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.21307\/immunohematology-2019-379","article-title":"Update on HDFN: new information on longstanding controversies","volume":"22","author":"Eder A","year":"2006","journal-title":"Immunohematology"},{"key":"e_1_2_6_3_1","volume-title":"Applied blood group serology","author":"Issitt PD","year":"1998"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420102"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1972.tb05894.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1984.24284173358.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1987.27688071692.x"},{"key":"e_1_2_6_8_1","unstructured":"Van der HartM MoseM van derVeerM et\u2009al.Ho and Lan\u2014two new blood group antigens. Proceedings of the Eighth Congress of the European Society of Haematology;1962. p.493."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1984.24685066820.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5662.90"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1983.23383224909.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1987.27187121460.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.12473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.12473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:42:22Z","timestamp":1696002142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.12473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,4]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/trf.12473"],"URL":"https:\/\/doi.org\/10.1111\/trf.12473","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,4]]}}}