{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:30:04Z","timestamp":1769218204174,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Background<\/jats:title>Transfusional iron overload and its consequences are challenges in chronically transfused patients with myelodysplastic syndromes (MDSs<\/jats:styled-content>) or aplastic anemia (AA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>This was a prospective, multicenter, open\u2010label study to investigate the efficacy of deferasirox (DFX<\/jats:styled-content>) by serial measurement of serum ferritin (S<\/jats:styled-content>\u2010ferritin) level, liver iron concentration (LIC<\/jats:styled-content>) level using relaxation rates magnetic resonance imaging, and other laboratory variables in patients with MDS<\/jats:styled-content> or AA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 96 patients showing S<\/jats:styled-content>\u2010ferritin level\u2009of at least 1000\u2009ng\/mL<\/jats:styled-content> received daily DFX<\/jats:styled-content> for up to 1 year. At the end of the study, S<\/jats:styled-content>\u2010ferritin level was significantly decreased in MDS<\/jats:styled-content> (p\u2009=\u20090.02366) and AA<\/jats:styled-content> (p\u2009=\u20090.0009). LIC<\/jats:styled-content> level was also significantly reduced by more than 6.7\u2009mg F<\/jats:styled-content>e\/g dry weight from baseline. Hemoglobin level and platelet counts were significantly increased from baseline (p\u2009=\u20090.002 and p\u2009=\u20090.025, respectively) for patients showing significant anemia or thrombocytopenia. Elevated alanine aminotransferase was also significantly decreased from baseline.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study shows that DFX<\/jats:styled-content> is effective in reducing S<\/jats:styled-content>\u2010ferritin and LIC<\/jats:styled-content> level in transfusional iron overload patients with MDS<\/jats:styled-content> or AA<\/jats:styled-content> and is well tolerated. In addition, positive effects in hematologic and hepatic function can be expected with DFX<\/jats:styled-content>. Iron chelation treatment should be considered in transfused patients with MDS<\/jats:styled-content> and AA<\/jats:styled-content> when transfusion\u2010related iron overload is documented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12507","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T04:45:25Z","timestamp":1386132325000},"page":"1542-1551","source":"Crossref","is-referenced-by-count":41,"title":["Deferasirox improves hematologic and hepatic function with effective reduction of serum ferritin and liver iron concentration in transfusional iron overload patients with myelodysplastic syndrome or aplastic anemia"],"prefix":"10.1111","volume":"54","author":[{"given":"June\u2010Won","family":"Cheong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University Seoul 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