{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:59:39Z","timestamp":1792792779035,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T00:00:00Z","timestamp":1389484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Background<\/jats:title>Transfusion reactions in pediatric populations have not been well studied. We investigated the incidence and type of transfusion reactions to platelets (PLTs<\/jats:styled-content>) in a pediatric inpatient population.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>Over 1\u2009year, a retrospective review of all PLT<\/jats:styled-content> transfusions given to pediatric inpatients (\u226418 years old) was performed at a single institution with application of the US<\/jats:styled-content> hemovigilance reporting definitions. Intraoperative transfusions were excluded. Any signs or symptoms that could represent an acute transfusion reaction (ATR<\/jats:styled-content>) within 24 hours after PLT<\/jats:styled-content> transfusion were reviewed and classified based on the US<\/jats:styled-content> hemovigilance reporting definitions.<\/jats:p><\/jats:sec>Results<\/jats:title>Between J<\/jats:styled-content>une 1, 2010, and M<\/jats:styled-content>ay 31, 2011, a total of 805 PLT<\/jats:styled-content> transfusions to 126 patients were identified as appropriate for inclusion. Of these 805 transfusions, 116 (14.4%) met the reporting criteria for ATR<\/jats:styled-content>s. Some PLT<\/jats:styled-content> transfusions were associated with multiple types of ATR<\/jats:styled-content>s leading to 120 ATR<\/jats:styled-content>s overall, as defined by the US<\/jats:styled-content> hemovigilance reporting system. Of these 120 reportable ATR<\/jats:styled-content>s, 54 (45.0%) transfusion\u2010associated dyspnea (TAD<\/jats:styled-content>) reactions, 38 (31.7%) febrile nonhemolytic transfusion reactions, 15 (12.5%) allergic transfusion reactions, eight (6.7%) hypotensive transfusion reactions, and five (4.2%) transfusion\u2010associated cardiac overload reactions were identified. No resultant deaths associated with ATR<\/jats:styled-content>s were observed. Of these reportable ATR<\/jats:styled-content>s, only four (3.34%) were reported to the hospital transfusion service.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings indicate that reportable ATR<\/jats:styled-content>s in the pediatric populations may be more prevalent than previously reported and were underreported to our transfusion service. TAD<\/jats:styled-content> encompassed the majority of reportable ATR<\/jats:styled-content>s and is the main contributor to the increased rate of reportable ATR<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12520","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T01:20:44Z","timestamp":1389576044000},"page":"1666-1672","source":"Crossref","is-referenced-by-count":30,"title":["Incidence of acute transfusion reactions to platelets in hospitalized pediatric patients based on the US<\/scp> hemovigilance reporting system"],"prefix":"10.1111","volume":"54","author":[{"given":"Ning","family":"Li","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanYun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.331094054613.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03322.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.10.012"},{"key":"e_1_2_7_5_1","unstructured":"AABB\/CDC Biovigilance Working Group.The National Healthcare Safety Network (NHSN) Manual: Biovigilance Component.2003. [cited 2013 Jun 26]. Available from:http:\/\/www.cdc.gov\/nhsn\/PDFs\/Biovigilance\/BV\u2010HV\u2010protocol\u2010current.pdf"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00995.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00070.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07022.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2006.05.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151349"},{"key":"e_1_2_7_11_1","unstructured":"TTISS Working Group.2004\u20102005 Program report for the National Transfusion Transmitted Injuries Surveillance System (TTISS) Public Health Agency of Canada.2008. [cited 2013 Jul 12]. 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