{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:39:57Z","timestamp":1789609197650,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Background<\/jats:title>To enhance donor availability, almost half of hematopoietic progenitor cell transplants (HPCTs<\/jats:styled-content>) cross ABO<\/jats:styled-content> blood type boundaries. ABO<\/jats:styled-content>\u2010incompatible HPCTs<\/jats:styled-content> are well tolerated; however, there is an increased risk of delayed hemolysis in patients with minor and bidirectional ABO<\/jats:styled-content> mismatches. Delayed hemolysis generally occurs 1 to 2 weeks after HPCT<\/jats:styled-content> and is related to production of alloantibodies directed against recipient ABO<\/jats:styled-content> red blood cell (RBC<\/jats:styled-content>) antigens by passenger donor lymphocytes. One previous study has suggested that prophylactic RBC<\/jats:styled-content> exchange in patients with minor and bidirectional ABO<\/jats:styled-content>\u2010mismatched HPCT<\/jats:styled-content> reduces the risks of severe immune hemolysis, but this recommendation is controversial.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>Herein we describe our experience using prophylactic RBC<\/jats:styled-content> exchange in patients with minor and bidirectional ABO<\/jats:styled-content>\u2010mismatched HPCT<\/jats:styled-content>s who were deemed to be at high risk for immune hemolysis. We compare the group of patients that received prophylactic RBC<\/jats:styled-content> exchange with a historical cohort of ABO<\/jats:styled-content>\u2010mismatched patients who underwent HPCT<\/jats:styled-content> without prophylactic RBC<\/jats:styled-content> exchange.<\/jats:p><\/jats:sec>Results<\/jats:title>Our study suggests that prophylactic RBC<\/jats:styled-content> exchange in minor and bidirectional ABO<\/jats:styled-content>\u2010mismatched HPCT<\/jats:styled-content> does not reduce severe immune hemolysis, nor does it improve 1\u2010year survival, the number of RBC<\/jats:styled-content> units transfused after transplant, or length of hospitalization after HPCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study failed to identify a clear role for selected prophylactic RBC<\/jats:styled-content> exchange in patients who were deemed at risk for severe post\u2010HPCT<\/jats:styled-content> immune hemolysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12529","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T10:28:46Z","timestamp":1387880926000},"page":"1857-1863","source":"Crossref","is-referenced-by-count":16,"title":["Prophylactic red blood cell exchange for ABO<\/scp>\u2010mismatched hematopoietic progenitor cell transplants"],"prefix":"10.1111","volume":"54","author":[{"given":"Robyn","family":"Cunard","sequence":"first","affiliation":[{"name":"Research Service and Division of Nephrology\u2010Hypertension Veterans Affairs San Diego Healthcare System Veterans Medical Research Foundation San Diego California"},{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isagani I.","family":"Marquez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie L.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Corringham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Clopton","sequence":"additional","affiliation":[{"name":"Research Service and Division of Nephrology\u2010Hypertension Veterans Affairs San Diego Healthcare System Veterans Medical Research Foundation San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber P.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pathology and Moore's Cancer Center University of California at San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1983.23483276858.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.135"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.001057"},{"key":"e_1_2_8_5_1","unstructured":"SzczepiorkowskiZM. 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