{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:26:18Z","timestamp":1790627178022,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3pt2","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of science and technology","award":["2006AA02Z453"],"award-info":[{"award-number":["2006AA02Z453"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Background<\/jats:title>The risk of hepatitis E<\/jats:styled-content> virus (HEV<\/jats:styled-content>) infection from blood transfusion has aroused increasing concern in many countries. The aim of this study was to analyze the potential risk of HEV<\/jats:styled-content> infection through blood transfusion in C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>Qualified blood donations and donations with isolated alanine aminotransferase (ALT<\/jats:styled-content>) elevations from five geographically diverse C<\/jats:styled-content>hinese regions were tested for anti\u2010HEV<\/jats:styled-content> immunoglobulin (Ig<\/jats:styled-content>)M<\/jats:styled-content> and IgG<\/jats:styled-content> and HEV<\/jats:styled-content> antigen. The positive samples for anti\u2010HEV IgM<\/jats:styled-content> and HEV<\/jats:styled-content> antigen were tested for HEV RNA<\/jats:styled-content>. HEV<\/jats:styled-content> open reading frame (ORF<\/jats:styled-content>)2 partial sequences were analyzed from HEV RNA<\/jats:styled-content>\u2013positive samples.<\/jats:p><\/jats:sec>Results<\/jats:title>The seroprevalence rates of HEV<\/jats:styled-content> antigen and anti\u2010HEV IgM<\/jats:styled-content> and IgG<\/jats:styled-content> among qualified donations were 0.06% (6\/10,741), 1.02% (109\/10,741), and 27.42% (2945\/10,741), respectively. Samples with isolated ALT<\/jats:styled-content> elevations had higher prevalence of HEV<\/jats:styled-content> markers, namely, HEV<\/jats:styled-content> antigen of 0.25% (2\/797), anti\u2010HEV IgM<\/jats:styled-content> of 2.76% (22\/797), and anti\u2010HEV IgG<\/jats:styled-content> of 40.02% (319\/797). The HEV<\/jats:styled-content> antibody prevalence varied significantly by age, sex, and geographic region. All 131 samples that were anti\u2010HEV IgM<\/jats:styled-content> positive were negative for HEV RNA<\/jats:styled-content>, whereas four of eight (50%) samples positive for HEV<\/jats:styled-content> antigen were HEV RNA<\/jats:styled-content> positive. HEV ORF<\/jats:styled-content>2 sequences from three of four HEV RNA<\/jats:styled-content>\u2013positive samples were determined and grouped with G<\/jats:styled-content>enotype 4.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Qualified donations after routine blood donor screening still carry potential risk for transmitting HEV<\/jats:styled-content>. HEV<\/jats:styled-content> antigen screening could be one measure to reduce the risk of HEV<\/jats:styled-content> transmission by blood transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12530","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T10:30:43Z","timestamp":1387881043000},"page":"910-917","source":"Crossref","is-referenced-by-count":60,"title":["Hepatitis E<\/scp> virus seroprevalence and molecular study among blood donors in C<\/scp>hina"],"prefix":"10.1111","volume":"54","author":[{"given":"Furong","family":"Ren","sequence":"first","affiliation":[{"name":"Beijing Red Cross Blood Center Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of HIV and Sexual Transmitted Virus Vaccine National Institutes for Food and Drug Control Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech 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