{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:18:15Z","timestamp":1774322295967,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Background<\/jats:title>Biological response modifiers (BRM<\/jats:styled-content>s), such as soluble CD<\/jats:styled-content>40 ligand (sCD<\/jats:styled-content>40L<\/jats:styled-content>); regulated upon activation, normal T<\/jats:styled-content>\u2010cell expressed, and secreted (RANTES<\/jats:styled-content>); and transforming growth factor\u2010\u03b21 (TGF<\/jats:styled-content>\u2010\u03b21), are released from platelets (PLTs<\/jats:styled-content>) during storage and may trigger adverse effects after PLT<\/jats:styled-content> transfusion. Although washing PLT<\/jats:styled-content>s is effective at reducing the level of BRM<\/jats:styled-content>s and the incidence of transfusion reactions, the washing procedure is time\u2010consuming and may induce PLT<\/jats:styled-content> activation. Furthermore, some BRM<\/jats:styled-content>s continue to accumulate during the storage of washed PLT<\/jats:styled-content>s. A method to remove BRM<\/jats:styled-content>s using adsorbent columns has not yet been developed.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>We evaluated the ability of columns packed with S<\/jats:styled-content>elesorb and L<\/jats:styled-content>iposorber beads, which are both clinically used, to remove BRM<\/jats:styled-content>s from PLT<\/jats:styled-content> concentrates (PC<\/jats:styled-content>s) stored for 5 days. The levels of these BRM<\/jats:styled-content>s were determined before and after adsorption.<\/jats:p><\/jats:sec>Results<\/jats:title>The adsorption columns significantly reduced the levels of RANTES<\/jats:styled-content> and sCD<\/jats:styled-content>40L<\/jats:styled-content> and partially reduced TGF<\/jats:styled-content>\u2010\u03b21. There were no significant effects on PLT<\/jats:styled-content> activation, aggregation, morphology, and plasma lactate dehydrogenase (an indicator of PLT<\/jats:styled-content> lysis) levels, or hypotonic shock response. Adsorption, however, reduced the PLT<\/jats:styled-content> recovery to approximately 60% of the untreated value.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study showed that the levels of BRM<\/jats:styled-content>s were substantially reduced using columns of clinically available adsorption beads. PLT<\/jats:styled-content> functions and the quality of PC<\/jats:styled-content>s were maintained after adsorption. The use of adsorption columns may be useful in reducing the incidence of nonhemolytic transfusion reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12542","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T07:41:10Z","timestamp":1389685270000},"page":"1790-1797","source":"Crossref","is-referenced-by-count":12,"title":["Removal of biological response modifiers associated with platelet transfusion reactions by columns containing adsorption beads"],"prefix":"10.1111","volume":"54","author":[{"given":"Shigenori","family":"Tanaka","sequence":"first","affiliation":[{"name":"Japanese Red Cross Kinki Block Blood Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kinki Block Blood Center Osaka 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