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Our aim was to propose standardized guidelines for the production and QC<\/jats:styled-content> of ASED<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>We conducted a nationwide survey consisting of questions regarding the methods used in each hospital for the production and QC<\/jats:styled-content> of ASED<\/jats:styled-content>s. The survey was sent by e\u2010mail to 89 doctors responsible for the blood banks at different hospitals.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010two hospitals replied, and 13 hospitals reported using the ASED<\/jats:styled-content>s in the treatment of patients with eye diseases. The screening test for patients, amount of blood sampling, type of bottle used for blood collection, details about the production of the eye drops, and storage methods and shelf life of unopened and opened bottles of eye drops varied between hospitals.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Based on an analysis of the survey results and a review of the standard operating procedures and protocols for ASED<\/jats:styled-content>s used in J<\/jats:styled-content>apan, G<\/jats:styled-content>ermany, E<\/jats:styled-content>ngland and W<\/jats:styled-content>ales, and the U<\/jats:styled-content>nited S<\/jats:styled-content>tates, we proposed standardized guidelines for the production and QC<\/jats:styled-content> of ASED<\/jats:styled-content>s in K<\/jats:styled-content>orea. ASED<\/jats:styled-content>s are not cell therapy products in the strictest sense. However, because eye drops are composed of serum isolated from blood and are used in patients, we consider ASED<\/jats:styled-content>s to be the basis for cell therapy products. Therefore, ASED<\/jats:styled-content>s should be produced and stored according to standardized guidelines based on the G<\/jats:styled-content>ood M<\/jats:styled-content>anufacturing P<\/jats:styled-content>ractice guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12558","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T02:46:56Z","timestamp":1394592416000},"page":"1864-1870","source":"Crossref","is-referenced-by-count":10,"title":["Proposal of standardized guidelines for the production and quality control of autologous serum eye drops in K<\/scp>orea: based on a nationwide survey"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-6441","authenticated-orcid":false,"given":"Hye Ryun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Gyeongsang National University Hospital Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Ji","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soie","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University Hospital Healthcare System Gangnam Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Mee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taek Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Un","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyou Sup","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00007-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.07.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01665.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1145"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.04.030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2011.01072.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270415"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90412-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702334"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703862"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.026211"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71962-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200111000-00006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200211000-00010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.4.390"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.044347"},{"key":"e_1_2_8_18_1","unstructured":"NHS Blood and Transplant.Autologous Serum Eyedrops Service.2008[cited 2013 May 20]. 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