{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:56:08Z","timestamp":1761155768869,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Background<\/jats:title>The use of hematopoietic progenitor cell (HPC<\/jats:styled-content>) transplant has risen over the past two decades. A variety of adverse events (AE<\/jats:styled-content>s) of varying severity have been noted during HPC<\/jats:styled-content> infusions. These AEs<\/jats:styled-content> have been associated with several factors such as the amount of dimethyl sulfoxide and white blood cells in the HPC<\/jats:styled-content> product. We performed a single\u2010institution retrospective analysis to determine the effect of two different HPC<\/jats:styled-content> infusion techniques, manual push with syringes versus infusion from bags with the aid of gravity, on the occurrence of infusion\u2010related AE<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>Infusions between D<\/jats:styled-content>ecember 2008 and N<\/jats:styled-content>ovember 2010 involving peripheral blood HPC<\/jats:styled-content>s were reviewed. Pertinent clinical and HPC<\/jats:styled-content> product\u2013related information was recorded. Data were analyzed to determine the incidence of infusion\u2010related AEs<\/jats:styled-content> and its association with patient and product\u2010related variables.<\/jats:p><\/jats:sec>Results<\/jats:title>We found 461 AEs<\/jats:styled-content> in 645 patients during the study period. A total of 325 (50%) experienced at least one AE<\/jats:styled-content>. Flushing was the most common type of AE<\/jats:styled-content> followed by nausea and hypertension. The use of syringe infusion was more commonly associated with AEs<\/jats:styled-content> (odds ratio, 1.82 [95% confidence interval, 1.32\u20102.50]; p\u2009=\u20090.002). Other independent risk factors were cryopreserved products and the amount of polymorphonuclear leukocytes in the product.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>To our knowledge, this is the first study examining the effect of two different infusion techniques on infusion\u2010related AEs<\/jats:styled-content>. Our findings suggest that the use of bags for infusion protected the patients from AEs<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12572","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T12:15:59Z","timestamp":1392639359000},"page":"1997-2003","source":"Crossref","is-referenced-by-count":22,"title":["Infusion technique of hematopoietic progenitor cells and related adverse events (CME)"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-1043","authenticated-orcid":false,"given":"Sudhanshu B.","family":"Mulay","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology University of Connecticut Health Center Farmington Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl W.","family":"Greiner","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Mohr","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra C.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics & Informatics Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi K.","family":"Lingineni","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics & Informatics Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Padley","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis A.","family":"Gastineau","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"},{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eapen K.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"226","article-title":"[Transfusions and grafts of homologous bone marrow in humans after accidental high dosage irradiation]","volume":"4","author":"Mathe G","year":"1959","journal-title":"Rev Fr Etud Clin Biol"},{"key":"e_1_2_7_3_1","unstructured":"PasquiniMC WangZ.Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides 2011.2011[cited 2012 Jul 5]. 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