{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:57:19Z","timestamp":1768085839978,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Background<\/jats:title>Determining the mechanism underlying the development of transfusion reactions is important in transfusion therapy. Two bags of fresh\u2010frozen plasma obtained from a donor (index donor) were implicated in two cases of anaphylactic transfusion reactions.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>The serum prepared from the index donor plasma transfused into the second patient (Patient\u20092<\/jats:styled-content>) was evaluated using cord blood\u2013derived mast cells (CBMCs<\/jats:styled-content>) incubated with P<\/jats:styled-content>atient\u20092 plasma. The component in the serum required for the degranulation was determined and quantified by chromatography in combination with degranulation assay, W<\/jats:styled-content>estern blot analysis, and enzyme\u2010linked immunosorbent assay. The component in the plasma required for CBMC<\/jats:styled-content> sensitization was determined using human immunoglobulin (Ig<\/jats:styled-content>)E<\/jats:styled-content> or normal plasma in place of P<\/jats:styled-content>atient\u20092 plasma in the assay. Sera collected from the index donor between 2001 and 2008 were examined for the CBMC<\/jats:styled-content> degranulation factor.<\/jats:p><\/jats:sec>Results<\/jats:title>The donor serum activated CBMCs<\/jats:styled-content> incubated with P<\/jats:styled-content>atient\u20092 plasma. The IgG<\/jats:styled-content> fraction of the donor serum induced degranulation of CBMC<\/jats:styled-content>s sensitized with IgE<\/jats:styled-content> or plasma containing a normal IgE concentration. The IgG<\/jats:styled-content> anti\u2010IgE<\/jats:styled-content> at a concentration higher than 2200\u2009ng\/mL<\/jats:styled-content>, which showed CBMC<\/jats:styled-content> degranulation activity, was detected in the donor sera for at least 7 years.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Transfusion of a high concentration of the anti\u2010IgE<\/jats:styled-content> in the donor plasma was suggested to induce mast cell degranulation in the patients leading to the development of anaphylactic transfusion reactions. Antibodies existing in not only the patient circulation but also the transfused blood might cause transfusion\u2010induced anaphylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12586","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T02:34:55Z","timestamp":1393900495000},"page":"1953-1960","source":"Crossref","is-referenced-by-count":8,"title":["Antibody against immunoglobulin E contained in blood components as causative factor for anaphylactic transfusion reactions"],"prefix":"10.1111","volume":"54","author":[{"given":"Takaaki","family":"Abe","sequence":"first","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Shimada","sequence":"additional","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoko","family":"Takanashi","sequence":"additional","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Cardiorenal Medicine Yokohama City University School of Medicine Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Motoji","sequence":"additional","affiliation":[{"name":"Motoji Medical Clinic Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Satake","sequence":"additional","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Tadokoro","sequence":"additional","affiliation":[{"name":"Central Blood Institute, Blood Service Headquarters Japanese Red Cross Society Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1999.77201101.x"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"165","article-title":"Haemovigilance data for five years by Japanese Red Cross Blood Service: transfusion\u2010related adverse reactions and infections from 2004 to 2008 [abstract]","volume":"97","author":"Momose S","year":"2009","journal-title":"Vox Sang"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2755"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114051"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00882.x"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"165","article-title":"Elevation of serum or plasma tryptase concentrations in patients with anaphylactic\/oid shock [abstract]","volume":"97","author":"Abe T","year":"2009","journal-title":"Vox Sang"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03126.x"},{"key":"e_1_2_8_9_1","first-page":"920","article-title":"Serum IgE levels in healthy children [in Japanese]","volume":"2","author":"Shimazu S","year":"1995","journal-title":"Allergol Immunol"},{"key":"e_1_2_8_10_1","first-page":"102","article-title":"Standards for ranges of 13 items of blood proteins among Japanese adults\u2014results of a joint project of 7 organizations based on NCCLS Document C28\u2010P and International Reference CRM470. 10. 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