{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:31:05Z","timestamp":1770895865945,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T00:00:00Z","timestamp":1395964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>After malaria, babesiosis is the second most common transfusion\u2010transmitted parasitic disease in the<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tates. In<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>urope, one reported transfusion case, concerning<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>abesia\u2009microti<\/jats:italic>, occurred in<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ermany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Due to the fact that<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>abesia<\/jats:italic>spp. are present in<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrolean ticks, the aim of this study is to assess the occurrence of immunoglobulin (<jats:styled-content style=\"fixed-case\">Ig<\/jats:styled-content>)<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>antibodies against the<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>abesia divergens<\/jats:italic>complex, including<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009divergens<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>abesia venatorum<\/jats:italic>(<jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>1), as well as<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009microti<\/jats:italic>by screening a representative collective of 988 blood donors from<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orth and<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ast<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrol (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustria) with indirect immunofluorescence antibody test. Additionally, we investigated 206 local ixodid ticks for the presence of babesial<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>by polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seroprevalence data resulted in rates of 2.1% for<jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content>antibodies against the<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009divergens<\/jats:italic>complex and 0.6% against<jats:italic><jats:styled-content style=\"fixed-case\">B.<\/jats:styled-content>\u2009microti<\/jats:italic>in<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrolean blood donors. All sera could be confirmed by independent retesting. Our data indicate that cross\u2010reactivity is high between<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009divergens<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009venatorum<\/jats:italic>and lower than 19.8% between<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009divergens<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">B.\u2009microti<\/jats:styled-content><\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>abesia<\/jats:italic>spp. are present in the<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrols, which blood donors come into serologic contact with, and that we have to consider how to sustain blood product safety concerning this new challenge. Additionally, it is the first description of<jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009venatorum<\/jats:italic>in the<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>yrols, found in one<jats:italic><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>xodes ricinus<\/jats:italic>at the<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>talian border.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12606","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T20:54:35Z","timestamp":1396040075000},"page":"1725-1732","source":"Crossref","is-referenced-by-count":19,"title":["Risk assessment of transfusion\u2010associated babesiosis in<scp>T<\/scp>yrol: appraisal by seroepidemiology and polymerase chain reaction"],"prefix":"10.1111","volume":"54","author":[{"given":"Sissy Therese","family":"Sonnleitner","sequence":"first","affiliation":[{"name":"Dr Gernot Walder GmbH Au\u00dfervillgraten Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Fritz","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Informatics and Health Economics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Bednarska","sequence":"additional","affiliation":[{"name":"Department of Parasitology Institute of Zoology Faculty of Biology University of Warsaw Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphaela","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Dr Gernot Walder GmbH Au\u00dfervillgraten Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Simeoni","sequence":"additional","affiliation":[{"name":"Service for Hygiene and Public Health Bozen Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Zelger","sequence":"additional","affiliation":[{"name":"Research Centre for Agriculture and Forestry Laimburg Pfatten Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Schennach","sequence":"additional","affiliation":[{"name":"Central Institute for Blood Transfusion and Immunology University Clinics Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Lass\u2010Fl\u00f6rl","sequence":"additional","affiliation":[{"name":"Department of Hygiene Medical Microbiology and Social Medicine Innsbruck Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Edelhofer","sequence":"additional","affiliation":[{"name":"Institute of Parasitology Department of Pathophylsiology University of Veterinary Medicine Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Pfister","sequence":"additional","affiliation":[{"name":"Veterinary Faculty Comparative Tropical Medicine and Parasitology Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Milhakov","sequence":"additional","affiliation":[{"name":"Veterinary Faculty Comparative Tropical Medicine and Parasitology Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Walder","sequence":"additional","affiliation":[{"name":"Dr Gernot Walder GmbH Au\u00dfervillgraten Austria"},{"name":"Central Institute for Blood Transfusion and Immunology University Clinics Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"141","volume-title":"Parasitic protozoa","author":"Kakoma I","year":"1993"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-426015-3.50006-6"},{"key":"e_1_2_8_4_1","first-page":"11","article-title":"Piroplasmosis in man; report of a case","volume":"9","author":"Skrabalo Z","year":"1957","journal-title":"Doc Med Geogr Trop"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1968.17.810"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003004669"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.7.2431-2436.2002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0807.010459"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0908.020748"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0333-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0255-0857(21)02536-6","article-title":"Human babesiosis\u2014a case report","volume":"23","author":"Marathe A","year":"2005","journal-title":"Indian J Med Microbiol"},{"key":"e_1_2_8_12_1","first-page":"699","article-title":"Human babesiosis\u2014a preliminary report of 2 suspected cases in South Africa","volume":"78","author":"Bush JB","year":"1990","journal-title":"S Afr Med J"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822003000400010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.11378"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/984568"},{"key":"e_1_2_8_16_1","first-page":"309","article-title":"Co\u2010infection with Borrelia species and other tick\u2010borne pathogens in humans: two cases from Poland","volume":"17","author":"Welc\u2010Faleciak R","year":"2010","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_8_17_1","volume-title":"The protozoan phylum Apicomplexa","author":"Levine ND","year":"1988"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1998.11813307"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.4.622-636.2003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2005.00748.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-7-199604010-00004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1004.030377"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200208293470921"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1373.077"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.01.002"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.03.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.431"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.6.1019"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2008.03.010"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2460\/javma.1991.199.05.601","article-title":"Hemolytic anemia caused by Babesia gibsoni infection in dogs","volume":"199","author":"Conrad PA","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/593812"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00245.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40030274.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00358.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1086\/595010"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02380.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02317.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00362"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00823-06"},{"key":"e_1_2_8_40_1","volume-title":"Acarology: mites and human welfare","author":"Woolley TA","year":"1988"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800323105"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807163390304"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00035-08"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.67018"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00022-10"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","unstructured":"BGBl. I Nr. 44\/1999 \u00a712.1999.","DOI":"10.1097\/00006123-199901000-00095"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01762.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03330040053031"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380190096034"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31491213305.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31491213290.x"},{"key":"e_1_2_8_52_1","volume-title":"Veterin\u00e4rmedizinische parasitologie","author":"Rommel M","year":"2006"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1958.11685862"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1973.11686877"},{"key":"e_1_2_8_55_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2460\/ajvr.1975.36.03.293","article-title":"Some observations on experimentally induced infection of dogs with Babesia gibsoni","volume":"36","author":"Botros BA","year":"1975","journal-title":"Am J Vet Res"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.2307\/3282004"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(90)90111-N"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-9571(96)00020-3"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.451-469.2000"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2002029"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(03)00130-4"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.01.039"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00766-07"},{"key":"e_1_2_8_64_1","first-page":"287","article-title":"Long term monitoring of Babesia microti infection in Balb\/c mice using nested PCR","volume":"14","author":"Welc\u2010Faleciak R","year":"2007","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2009008"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2009020"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1981.30.555"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.03.008"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90008-9"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.12606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.12606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T05:52:47Z","timestamp":1746165167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.12606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,28]]},"references-count":68,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/trf.12606"],"URL":"https:\/\/doi.org\/10.1111\/trf.12606","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,28]]}}}