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This study's objective was to assess <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> occurrence and potential risk factors among inpatient <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> elderly <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicare beneficiaries, ages 65 and older, during 2007 through 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>This retrospective claims\u2010based study utilized large <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicare administrative databases. Transfusions were identified by recorded procedure and revenue center codes. <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> was ascertained via <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u20109\u2010<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> diagnosis code. The study evaluated <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> rates among the inpatient elderly overall and by calendar year, age, sex, race, blood components, and units transfused. Logistic regression analyses were used to assess potential risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 11,378,264 inpatient transfusion stays for elderly <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicare beneficiaries, 2556 had a recorded <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> diagnosis code, an overall rate of 22.46 per 100,000 stays. <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> rates were higher for platelet (PLT)\u2010 and plasma\u2010containing transfusions and increased by year and number of units transfused (p\u2009&lt;\u20090.0001). Significantly higher odds of <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> were also found for persons ages 65 to 79 years versus more than 79 years (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.19; 95% confidence interval <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.09\u20101.29), females versus males (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.26; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.16\u20101.38), white versus nonwhite (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.43; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.27\u20101.66), and with 6\u2010month histories of postinflammatory pulmonary fibrosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.89; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.52\u20102.20), tobacco use (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.16; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.00\u20101.26), and other diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study among the elderly suggests <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> to be a severe event and identifies a substantially increased <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> occurrence with greater number of units and with <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\u2010 or plasma\u2010containing transfusions. The study also suggests importance of underlying health conditions, prior recipient alloimmunization, and nonimmune mechanism in <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> development among the elderly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12626","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T20:55:46Z","timestamp":1396040146000},"page":"2182-2193","source":"Crossref","is-referenced-by-count":39,"title":["Transfusion\u2010related acute lung injury and potential risk factors among the inpatient <scp>US<\/scp> elderly as recorded in <scp>M<\/scp>edicare claims data, during 2007 through 2011"],"prefix":"10.1111","volume":"54","author":[{"given":"Mikhail","family":"Menis","sequence":"first","affiliation":[{"name":"Food and Drug Administration  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Food and Drug Administration  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Forshee","sequence":"additional","affiliation":[{"name":"Food and Drug Administration  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McKean","sequence":"additional","affiliation":[{"name":"Acumen LLC  Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Johnson","sequence":"additional","affiliation":[{"name":"Acumen LLC  Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Warnock","sequence":"additional","affiliation":[{"name":"Acumen LLC  Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Gondalia","sequence":"additional","affiliation":[{"name":"Acumen LLC  Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Food and Drug Administration  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Holness","sequence":"additional","affiliation":[{"name":"Food and Drug Administration  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Worrall","sequence":"additional","affiliation":[{"name":"Centers for Medicare &amp; Medicaid Services  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Kelman","sequence":"additional","affiliation":[{"name":"Centers for Medicare &amp; Medicaid Services  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector S.","family":"Izurieta","sequence":"additional","affiliation":[{"name":"Food and Drug Administration  Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"US Food and Drug Administration Center for Biologics Evaluation & Research.Fatalities reported to FDA following blood collection and transfusion: annual summary for fiscal year 2011.2012[cited 2013 Mar 25]. 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