{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:48:31Z","timestamp":1790362111209,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Background<\/jats:title>It is not clear whether red blood cell (RBC<\/jats:styled-content>) transfusions typically increase a neonate's total serum bilirubin (TSB<\/jats:styled-content>) level or if so by how much.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>In this retrospective analysis, from 2009 through 2012, we collected TSB<\/jats:styled-content> measurements before and after transfusions, recording blood types of mothers, neonates, and blood donors and whether phototherapy was used before, during, or after transfusion.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 7272 neonates admitted during this period, 658 (9%) received 2597 RBC<\/jats:styled-content> transfusions. TSB<\/jats:styled-content> levels were drawn before and after 431 transfusions, 255 of which did not have phototherapy at the time the transfusion was administered. The mean increase in TSB<\/jats:styled-content> was 2.2\u2009mg\/dL<\/jats:styled-content> (95% confidence interval, 1.9\u20102.5\u2009mg\/dL<\/jats:styled-content>). Seven percent of all transfusions and 12% of transfusions to very\u2010low\u2010birthweight (VLBW<\/jats:styled-content>) infants (<1500\u2009g) were followed by a TSB<\/jats:styled-content> increase of at least 5\u2009mg\/dL<\/jats:styled-content>. Transfusions with \u201cuniversal donor\u201d blood (O<\/jats:styled-content>\u2013) resulted in a higher TSB<\/jats:styled-content> increase (p\u2009<\u20090.0001), but the magnitude was clinically insignificant (0.3\u2009mg\/dL<\/jats:styled-content>). Older blood (days since donor draw) did not generate significantly higher posttransfusion TSB<\/jats:styled-content> levels (p\u2009=\u20090.092). A focused study of the 10 neonates with the highest TSB<\/jats:styled-content> increases revealed that six were unexplained other than transfusion related.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We describe an association between RBC<\/jats:styled-content> transfusion and TSB<\/jats:styled-content> elevation, but we recognize that this does not establish a cause\u2010and\u2010effect relationship. However, the observation that an increase of at least 5\u2009mg\/dL<\/jats:styled-content> occurs after 12% of transfusions to VLBW<\/jats:styled-content> neonates suggests to us that clinicians will want to evaluate jaundice, or measure bilirubin, on VLBW<\/jats:styled-content> neonates after transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12716","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T11:16:32Z","timestamp":1401880592000},"page":"3068-3074","source":"Crossref","is-referenced-by-count":7,"title":["Association of neonatal red blood cell transfusion with increase in serum bilirubin"],"prefix":"10.1111","volume":"54","author":[{"given":"Robert D.","family":"Christensen","sequence":"first","affiliation":[{"name":"Women and Newborns Program Ogden Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie L.","family":"Baer","sequence":"additional","affiliation":[{"name":"Women and Newborns Program Ogden Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Snow","sequence":"additional","affiliation":[{"name":"Statistical Data Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Butler","sequence":"additional","affiliation":[{"name":"Statistical Data Center Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Ilstrup","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Services Intermountain Healthcare Murray Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.10.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.02.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.134056"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.08.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104813"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.23"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02823.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03394.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000302719"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02172.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2791"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1542\/peds.93.6.996","article-title":"Kernicterus 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