{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:10:28Z","timestamp":1791263428963,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T00:00:00Z","timestamp":1401148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion\u2010related acute lung injury (<jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content>) is known as a life\u2010threatening complication of transfusion. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HNA<\/jats:styled-content> antibodies have been associated with the immune pathway of <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content>. Since donors with a history of transfusion and\/or pregnancy are presumed to have an increased risk of carrying such antibodies, we investigated the association of a history of transfusion or pregnancy with the occurrence of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alloimmunization in our donor population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A total of 1018 female plateletpheresis donors and male plateletpheresis donors with a history of transfusion were enrolled in the study. Included donors were systematically screened, using <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>uminex technology, for anti\u2010<jats:styled-content style=\"fixed-case\">HLA C<\/jats:styled-content>lass <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. The association of donor history with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alloimmunization status was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall alloimmunization rate was 20.2%. In 0.0% of the nulliparous transfused female donors and in 1.3% of the transfused male donors, anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> were detected. Thirty\u2010one percent of the parous women versus 4.2% of the nulliparous women screened positive for anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>. The rate of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alloimmunization increased with parity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that a history of transfusion is a minor risk factor for immunization against <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antigens. In contrast, former pregnancies constitute a major risk factor for the development of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies. Since <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alloimmunization rate increases with parity, <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> risk reduction measures should focus on this particular donor population. Repeated testing of female plateletpheresis donors after each pregnancy is implemented in our blood service.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12727","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T07:48:29Z","timestamp":1401176909000},"page":"3036-3042","source":"Crossref","is-referenced-by-count":44,"title":["Screening for <scp>HLA<\/scp> antibodies in plateletpheresis donors with a history of transfusion or pregnancy"],"prefix":"10.1111","volume":"54","author":[{"given":"Dorien","family":"De Clippel","sequence":"first","affiliation":[{"name":"Blood Service Belgian Red Cross\u2010Flanders  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Baeten","sequence":"additional","affiliation":[{"name":"Blood Service Belgian Red Cross\u2010Flanders  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneleen","family":"Torfs","sequence":"additional","affiliation":[{"name":"Laboratory for Histocompatibility and Immunogenetics Belgian Red Cross\u2010Flanders  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Paule","family":"Emonds","sequence":"additional","affiliation":[{"name":"Laboratory for Histocompatibility and Immunogenetics Belgian Red Cross\u2010Flanders  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik B.","family":"Feys","sequence":"additional","affiliation":[{"name":"Transfusion Research Center Belgian Red Cross\u2010Flanders  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Compernolle","sequence":"additional","affiliation":[{"name":"Blood Service Belgian Red Cross\u2010Flanders  Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Vandekerckhove","sequence":"additional","affiliation":[{"name":"Blood Service Belgian Red Cross\u2010Flanders  Gent Belgium"},{"name":"Department of Public Health and Primary Care Catholic University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1985.25686071434.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00920.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41101244.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1703.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02751.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286146"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2008.01092.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370932"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200702-271OC"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03120.x"},{"key":"e_1_2_7_12_1","unstructured":"US Food and Drug Administration.Fatalities reported to FDA following blood collection and transfusion annual summary for fiscal year 2010. 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