{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:19:15Z","timestamp":1792253955740,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusion\u2010related acute lung injury (<jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content>) is a severe transfusion reaction that manifests as acute respiratory compromise within 6 hours of the infusion of blood products. Intravenous immune globulin (<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>) is prepared from large pools of human plasma and is commonly administered in the outpatient setting for the treatment of a wide range of diseases. As a plasma\u2010derived blood product, <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> may also cause <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content>, although reports of this are exceedingly rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 77\u2010year\u2010old female with common variable immune deficiency had been receiving <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> since 1996 for infection prophylaxis. During a scheduled infusion, the patient developed hypertension and dyspnea, requiring increasing oxygen supplementation and subsequent intubation. Radiographic studies demonstrated the bilateral chest infiltrates, with no evidence of infection or circulatory overload. The patient was extubated after 24 hours and discharged several days later. The patient had not previously received this lot of <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> and has since received further transfusions with different lot numbers of the same product without incident.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case report documents a case of <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> transfusion. While a very rare cause, this case furthers evidence that <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> can occur after <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content> transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12731","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T09:34:56Z","timestamp":1401960896000},"page":"3088-3091","source":"Crossref","is-referenced-by-count":14,"title":["Transfusion\u2010related acute lung injury after transfusion of pooled immune globulin: a case report"],"prefix":"10.1111","volume":"54","author":[{"given":"Graeme R.","family":"Quest","sequence":"first","affiliation":[{"name":"Transfusion Medicine, Edmonton Zone Alberta Health Services  Edmonton Alberta Canada"},{"name":"Laboratory Medicine and Pathology Faculty of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Gaal","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, Edmonton Zone Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen","family":"Clarke","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, Edmonton Zone Alberta Health Services  Edmonton Alberta Canada"},{"name":"Laboratory Medicine and Pathology Faculty of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Nahirniak","sequence":"additional","affiliation":[{"name":"Transfusion Medicine, Edmonton Zone Alberta Health Services  Edmonton Alberta Canada"},{"name":"Laboratory Medicine and Pathology Faculty of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1009433"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.09.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.09.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2007.01.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2007.01.001"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"79","article-title":"Side\u2010effects of intravenous immune globulins","volume":"97","author":"Duhem C","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04347.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000159849.94750.51"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370932"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02652.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01948.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.11.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21185"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41020264.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2012.01645.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.12731","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.12731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:35:26Z","timestamp":1695508526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.12731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,5]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/trf.12731"],"URL":"https:\/\/doi.org\/10.1111\/trf.12731","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,5]]}}}