{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:38:58Z","timestamp":1792827538118,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["171002206"],"award-info":[{"award-number":["171002206"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Prophylactic use of fresh\u2010frozen plasma (\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      ) is common practice in patients with a coagulopathy undergoing an invasive procedure. Evidence that\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      prevents bleeding is lacking, while risks of transfusion\u2010related morbidity after\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      have been well demonstrated. We aimed to assess whether omitting prophylactic\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      transfusion in nonbleeding critically ill patients with a coagulopathy who undergo an intervention is noninferior to a prophylactic transfusion of\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>\n                      A multicenter randomized open\u2010label trial with blinded endpoint evaluation was performed in critically ill patients with a prolonged international normalized ratio (\n                      <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n                      ; 1.5\u20103.0). Patients undergoing placement of a central venous catheter, percutaneous tracheostomy, chest tube, or abscess drainage were eligible. Patients with clinically overt bleeding, thrombocytopenia, or therapeutic use of anticoagulants were excluded. Patients were randomly assigned to omitting or administering a prophylactic transfusion of\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      (12\u2009\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      \/kg). Outcomes were occurrence of postprocedural bleeding complications,\n                      <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n                      correction, and occurrence of lung injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Due to slow inclusion, the trial was stopped before the predefined target enrollment was reached. Eighty\u2010one patients were randomly assigned, 40 to\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      and 41 to no\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      transfusion. Incidence of bleeding did not differ between groups, with a total of one major and 13 minor bleedings (p\u2009=\u20090.08 for noninferiority).\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      transfusion resulted in a reduction of\n                      <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>\n                      to less than 1.5 in 54% of transfused patients. No differences in lung injury scores were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In critically ill patients undergoing an invasive procedure, no difference in bleeding complications was found regardless whether\n                      <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>\n                      was prophylactically administered or not.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.12750","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:09:28Z","timestamp":1402358968000},"page":"26-35","source":"Crossref","is-referenced-by-count":117,"title":["Transfusion of fresh\u2010frozen plasma in critically ill patients with a coagulopathy before invasive procedures: a randomized clinical trial (CME)"],"prefix":"10.1111","volume":"55","author":[{"given":"Marcella C.","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Sesmu","family":"Arbous","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique M.","family":"Spoelstra\u2010de Man","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine VU Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Vink","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tergooiziekenhuizen  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"Karakus","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Diakonessenhuis  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Straat","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Binnekade","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evert","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreeth B.","family":"Vroom","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole P.","family":"Juffermans","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Center  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04972.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2008.079"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.00427.x"},{"key":"e_1_2_7_5_1","unstructured":"Serious Hazards of Transfusion Steering Committee.Serious hazards of transfusion: annual report.2012. 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