{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:52:15Z","timestamp":1789825935904,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Background<\/jats:title>A recent NHLBI<\/jats:styled-content> conference concluded that platelet (PLT<\/jats:styled-content>) transfusions of neonates must become more evidence based. One neonatal disorder for which transfusions are given is a poorly defined entity, the \u201cthrombocytopenia of perinatal asphyxia.\u201d To expand the evidence base for this entity, we performed a multicentered, retrospective analysis of neonates with perinatal asphyxia.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>We analyzed records of term and late preterm neonates with perinatal asphyxia defined by a cord blood pH<\/jats:styled-content> of not more than 6.99 and\/or base deficit of at least 16\u2009mmol\/L<\/jats:styled-content>. From these we identified neonates with at least two PLT<\/jats:styled-content> counts of fewer than 150\u2009\u00d7\u2009109<\/jats:sup>\/L<\/jats:styled-content> in the first week of life and described the severity, nadir, and duration of the thrombocytopenia.<\/jats:p><\/jats:sec>Results<\/jats:title>Thrombocytopenia occurred in 31% (117\/375) of neonates with asphyxia versus 5% of matched nonasphyxiated controls admitted to a neonatal intensive care unit (p\u2009<\u20090.0001). Twenty\u2010one of the 117 asphyxiated neonates were excluded from the remaining analysis due to disseminated intravascular coagulation or extracorporeal membrane oxygenation. Nadir PLT<\/jats:styled-content> counts of the remaining 96 were on D<\/jats:styled-content>ay 3 (75\u2009\u00d7\u2009109<\/jats:sup>\/L<\/jats:styled-content>; 90% confidence interval, 35.7\u2009\u00d7\u2009109<\/jats:sup>\u2010128.6\u2009\u00d7\u2009109<\/jats:sup>\/L<\/jats:styled-content>) and normalized by D<\/jats:styled-content>ays 19 to 21. PLT<\/jats:styled-content> counts after asphyxia roughly correlated inversely with elevated nucleated red blood cell count (NRBC<\/jats:styled-content>) counts at birth. Thirty of the 96 received at least one PLT<\/jats:styled-content> transfusion, all given prophylactically, none for bleeding.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We maintain that the thrombocytopenia of perinatal asphyxia is an authentic entity. Its association with elevated NRBC<\/jats:styled-content> counts suggests that hypoxia is involved in the pathogenesis. Because PLT<\/jats:styled-content> counts are only moderately low, the condition is transient, and bleeding problems seem rare, we speculate that PLT<\/jats:styled-content> transfusions should not be needed for most neonates with this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12777","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T06:52:00Z","timestamp":1408603920000},"page":"187-196","source":"Crossref","is-referenced-by-count":36,"title":["Thrombocytopenia in late preterm and term neonates after perinatal asphyxia"],"prefix":"10.1111","volume":"55","author":[{"given":"Robert D.","family":"Christensen","sequence":"first","affiliation":[{"name":"Women and Newborn's Clinical Program Intermountain Healthcare Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie L.","family":"Baer","sequence":"additional","affiliation":[{"name":"Women and Newborn's Clinical Program Intermountain Healthcare Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan M.","family":"Yaish","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12343"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02898.x"},{"key":"e_1_2_8_4_1","first-page":"162","volume-title":"Neonatal hematology","author":"Sola\u2010Visner MC","year":"2013"},{"key":"e_1_2_8_5_1","first-page":"94","volume-title":"Neonatal encephalopathy and neurologic outcome","author":"Task Force on Neonatal Encephalopathy","year":"2014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_8_8_1","unstructured":"American Academy of Pediatrics American College of Obstetricians and Gynecologists.Neonatal encephalopathy and cerebral palsy: defining the pathogenesis and pathophysiology. 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