{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:14:42Z","timestamp":1780542882506,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) is associated with chronic hemolysis and painful episodes. Pregnancy accelerates sickle cell complications, including prepartum and postpartum vasoocclusive crisis, pulmonary complications, and preeclampsia or eclampsia. Fetal complications include preterm birth and its associated risks, intrauterine growth restriction, and a high rate of perinatal mortality. The purpose of this study was to evaluate pregnancy outcomes in patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> who underwent planned preventive red blood cell exchange (<jats:styled-content style=\"fixed-case\">RBCX<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We retrospectively evaluated the complications of <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> in 37 pregnant patients. Patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> who had undergone prophylactic <jats:styled-content style=\"fixed-case\">RBCX<\/jats:styled-content> were compared with a control group who had not undergone <jats:styled-content style=\"fixed-case\">RBCX<\/jats:styled-content> during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three exchange procedures were performed in 24 patients. The control group comprised 13 patients with a mean age of 27.4\u2009\u00b1\u20093.3 years who had not undergone <jats:styled-content style=\"fixed-case\">RBCX<\/jats:styled-content> during pregnancy. Four of the five patients who developed a vasoocclusive crisis died. There was a significant difference in maternal mortality between the study and control groups (p\u2009=\u20090.011). There was also a significant difference in the incidence of vasoocclusive crisis between the study and control groups. One fetal death occurred in the 20th gestational week in a patient in the control group, although there were no postpartum complications in either the babies or the mothers in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study has demonstrated that prophylactic <jats:styled-content style=\"fixed-case\">RBCX<\/jats:styled-content> during pregnancy is a feasible and safe procedure for prevention of complications. Given the decrease in the risks of transfusion, <jats:styled-content style=\"fixed-case\">RBCX<\/jats:styled-content> warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12780","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T09:07:58Z","timestamp":1406624878000},"page":"36-44","source":"Crossref","is-referenced-by-count":47,"title":["Prophylactic red blood cell exchange may be beneficial in the management of sickle cell disease in pregnancy"],"prefix":"10.1111","volume":"55","author":[{"given":"Suheyl","family":"Asma","sequence":"first","affiliation":[{"name":"Clinical Unit Baskent University Adana Adult Bone Marrow Transplantation Center  Ankara Turkey"},{"name":"Department of Family Medicine Baskent University Medical Faculty  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur","family":"Kozanoglu","sequence":"additional","affiliation":[{"name":"Cell Collecting and Therapeutic Apheresis Unit 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