{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:05:42Z","timestamp":1792101942004,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Background<\/jats:title>Posttransfusion purpura (PTP<\/jats:styled-content>) is a serious transfusion complication resulting in sudden thrombocytopenia with bleeding. The study's objective was to assess PTP<\/jats:styled-content> occurrence and potential risk factors among the inpatient US elderly, ages 65 and older, during 2011 through 2012.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>This retrospective claims\u2010based study utilized large M<\/jats:styled-content>edicare databases for calendar years 2011 and 2012. Transfusions of blood and blood components were identified by recorded ICD<\/jats:styled-content>\u20109\u2010CM<\/jats:styled-content> procedure codes and revenue center codes, and PTP<\/jats:styled-content> was ascertained via ICD<\/jats:styled-content>\u20109\u2010CM<\/jats:styled-content> diagnosis code. Our study evaluated PTP<\/jats:styled-content> rates (per 100,000 inpatient transfusion stays) among elderly M<\/jats:styled-content>edicare beneficiaries, overall and by age, sex, race, number of units, and blood components transfused. Multivariate regression analyses were used to assess potential risk factors.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 4,336,338 inpatient transfusion stays for elderly beneficiaries during the study period, 78 had a PTP<\/jats:styled-content> diagnosis code recorded, an overall rate of 1.8 per 100,000 stays. PTP<\/jats:styled-content> occurrence varied by the blood components, units transfused, and other characteristics. Significantly higher odds of PTP<\/jats:styled-content> were found for platelet (PLT<\/jats:styled-content>)\u2010containing transfusions, with greater number of units transfused, as well as for elderly with histories of cardiac arrhythmias (odds ratio [OR<\/jats:styled-content>],\u20092.65; 95% confidence interval [CI<\/jats:styled-content>], 1.43\u20104.93), coagulopathy (OR<\/jats:styled-content>,\u20091.79; 95% CI<\/jats:styled-content>, 1.01\u20103.21), leukemia (OR<\/jats:styled-content>,\u20092.37; 95% CI<\/jats:styled-content>, 1.07\u20105.26), transplant (OR<\/jats:styled-content>,\u20092.68; 95% CI<\/jats:styled-content>, 1.41\u20105.09), and other conditions.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our population\u2010based study suggests a substantially higher PTP<\/jats:styled-content> risk with PLT<\/jats:styled-content>\u2010containing transfusions. The study also suggests increased PTP<\/jats:styled-content> risk with greater number of units transfused as well as the importance of underlying health conditions and prior recipient alloimmunization for PTP<\/jats:styled-content> occurrence among the elderly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12782","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T09:10:36Z","timestamp":1406538636000},"page":"284-295","source":"Crossref","is-referenced-by-count":28,"title":["Posttransfusion purpura occurrence and potential risk factors among the inpatient US elderly, as recorded in large M<\/scp>edicare databases during 2011 through 2012"],"prefix":"10.1111","volume":"55","author":[{"given":"Mikhail","family":"Menis","sequence":"first","affiliation":[{"name":"Food and Drug Administration Silver Spring Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Forshee","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McKean","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Gondalia","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Warnock","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Johnson","sequence":"additional","affiliation":[{"name":"Acumen LLC Burlingame California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Worrall","sequence":"additional","affiliation":[{"name":"Centers for Medicare & Medicaid Services Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Kelman","sequence":"additional","affiliation":[{"name":"Centers for Medicare & Medicaid Services Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector S.","family":"Izurieta","sequence":"additional","affiliation":[{"name":"Food and Drug Administration Silver Spring Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"275","volume-title":"Transfusion reactions","author":"McFarland JG","year":"2007"},{"key":"e_1_2_7_3_1","unstructured":"Public Health Agency of Canada.Transfusion transmitted injuries. 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