{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:44:14Z","timestamp":1791081854597,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Background<\/jats:title>Patients with congenital F<\/jats:styled-content>actor XIII<\/jats:styled-content> (FXIII<\/jats:styled-content>) deficiency have impaired fibrin stabilization and are at high risk for surgical bleeding. Data regarding the use of FXIII<\/jats:styled-content> concentrates before and during surgery are lacking. The objective of this study was to report the use of plasma\u2010derived FXIII<\/jats:styled-content> concentrate (C<\/jats:styled-content>orifact in the U<\/jats:styled-content>nited S<\/jats:styled-content>tates; F<\/jats:styled-content>ibrogammin P<\/jats:styled-content> in other countries) in patients with congenital FXIII<\/jats:styled-content> deficiency undergoing surgical procedures.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>FXIII<\/jats:styled-content> concentrate at preoperative doses ranging from 25 to 40\u2009U<\/jats:styled-content>\/kg was administered to six patients with congenital FXIII<\/jats:styled-content> deficiency undergoing major or minor surgeries.<\/jats:p><\/jats:sec>Results<\/jats:title>FXIII<\/jats:styled-content> concentrate was administered immediately before surgery for five surgical cases; three of these patients achieved excellent hemostasis during and after surgery, while two had intraoperative bleeding. In one surgical case, a regular prophylactic dose of FXIII<\/jats:styled-content> concentrate was administered to the patient 1 week before minor surgery. FXIII<\/jats:styled-content> concentrate provided rapid replacement of FXIII<\/jats:styled-content> activity. In all but one of the patients given a dose of FXIII<\/jats:styled-content> designed to increase FXIII<\/jats:styled-content> levels more than 50%, there was satisfactory intraoperative and postoperative hemostasis. One patient undergoing aortic valve replacement on cardiopulmonary bypass (CPB<\/jats:styled-content>) was the exception. Intraoperative bleeding in this patient was associated with lower\u2010than\u2010expected blood levels of FXIII<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Preoperative plasma\u2010derived FXIII<\/jats:styled-content> concentrate allowed for sufficient hemostasis in most patients with FXIII<\/jats:styled-content> deficiencies. Additional doses were necessary to achieve hemostasis in one patient who underwent a CPB<\/jats:styled-content> procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12784","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T09:08:21Z","timestamp":1406624901000},"page":"45-50","source":"Crossref","is-referenced-by-count":22,"title":["Use of F<\/scp>actor XIII<\/scp> (FXIII) concentrate in patients with congenital FXIII deficiency undergoing surgical procedures"],"prefix":"10.1111","volume":"55","author":[{"given":"Maissaa","family":"Janbain","sequence":"first","affiliation":[{"name":"Tulane University School of Medicine New Orleans Louisiana Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane J.","family":"Nugent","sequence":"additional","affiliation":[{"name":"Children's Hospital of Orange County Orange California Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry S.","family":"Powell","sequence":"additional","affiliation":[{"name":"UC Davis Comprehensive Cancer Center Sacramento California Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"St\u2010Louis","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al and H\u00e9matologie\u2010Oncologie, H\u00f4pital Maisonneuve\u2010Rosemont Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia B.","family":"Frame","sequence":"additional","affiliation":[{"name":"CSL Behring King of Prussia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy A.","family":"Leissinger","sequence":"additional","affiliation":[{"name":"Tulane University School of Medicine New Orleans Louisiana Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01857.x"},{"key":"e_1_2_7_3_1","unstructured":"National Hemophilia Foundation.Factor XIII (fibrin stabilizing factor) deficiency. 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Available from:http:\/\/www.hemophilia.org\/Bleeding\u2010Disorders\/Types\u2010of\u2010Bleeding\u2010Disorders\/Other\u2010Factor\u2010Deficiencies\/Factor\u2010XIII"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1515\/cclm-2011-0730","article-title":"Measurement of factor XIII activity in plasma","volume":"50","author":"Katona E","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00469.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134800.46276.21"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000017219.83330.FF"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00338.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.03.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02118.x"},{"key":"e_1_2_7_11_1","volume-title":"Corifact\u00ae (factor XIII concentrate [human]) [prescribing information]","author":"CSL Behring LLC","year":"2011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02123.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04281.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(13)70005-7"},{"key":"e_1_2_7_15_1","volume-title":"Tretten\u00ae (catridecagog) [prescribing information]","author":"Novo Nordisk Canada Inc","year":"2012"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-12-0799"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200103000-00003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0595"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00944.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.12784","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.12784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.12784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.12784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:40:14Z","timestamp":1695555614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.12784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,29]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/trf.12784"],"URL":"https:\/\/doi.org\/10.1111\/trf.12784","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,29]]}}}