{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:34:10Z","timestamp":1789072450785,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>How platelet (<jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>) product characteristics such as dose, source (whole blood derived [<jats:styled-content style=\"fixed-case\">WBD<\/jats:styled-content>] vs. apheresis), storage duration, and <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> matching status affect the risks of transfusion\u2010related adverse events (<jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content>s) is unclear. Similarly, more information is needed to define how recipient characteristics affect the frequency of <jats:styled-content style=\"fixed-case\">TRAEs<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>In the multicenter <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>latelet <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ose (\u201c<jats:styled-content style=\"fixed-case\">PLADO<\/jats:styled-content>\u201d) study, pediatric and adult hematology\u2010oncology patients with hypoproliferative thrombocytopenia were randomized to receive low\u2010dose (<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>), medium\u2010dose (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>), or high\u2010dose (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> prophylaxis for a pretransfusion <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> count of not more than 10\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>. All <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> units (apheresis or <jats:styled-content style=\"fixed-case\">WBD<\/jats:styled-content>) were leukoreduced. Post hoc analyses of <jats:styled-content style=\"fixed-case\">PLADO<\/jats:styled-content> data were performed using multipredictor models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5034 <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> transfusions to 1102 patients were analyzed. A <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content> occurred with 501 <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> transfusions (10.0%). The most common <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content>s were fever (6.6% of transfusions), allergic or hypersensitivity reactions (1.9%), and sinus tachycardia (1.8%). Patients assigned <jats:styled-content style=\"fixed-case\">HD PLTs<\/jats:styled-content> were more likely than <jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> patients to experience any <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content> (odds ratio for <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> vs. <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>, 1.50; 95% confidence interval, 1.10\u20102.05; three\u2010group comparison p\u2009=\u20090.02). <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> source and <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> matching status were not significantly related to overall <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content> risk. Compared to a patient's first <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> transfusion, subsequent <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> transfusions were less likely to have a <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content> reported, primarily due to a lower risk of allergic or hypersensitivity reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most important <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> unit characteristic associated with <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content>s was <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> dose per transfusion. <jats:styled-content style=\"fixed-case\">HD PLT<\/jats:styled-content>s may increase the risk of <jats:styled-content style=\"fixed-case\">TRAE<\/jats:styled-content>s, and <jats:styled-content style=\"fixed-case\">LD PLT<\/jats:styled-content>s may reduce the risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12791","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T09:09:10Z","timestamp":1406538550000},"page":"144-153","source":"Crossref","is-referenced-by-count":90,"title":["Transfusion\u2010related adverse events in the <scp>P<\/scp>latelet <scp>D<\/scp>ose study"],"prefix":"10.1111","volume":"55","author":[{"given":"Richard M.","family":"Kaufman","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan F.","family":"Assmann","sequence":"additional","affiliation":[{"name":"Center for Statistical Analysis and Research New England Research Institutes  Watertown Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell J.","family":"Triulzi","sequence":"additional","affiliation":[{"name":"Department of Pathology Division of Transfusion Medicine University of Pittsburgh  Pittsburgh Pennsylvania"},{"name":"University of Iowa College of Medicine  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Strauss","sequence":"additional","affiliation":[{"name":"University of Iowa College of Medicine  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ness","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Division Johns Hopkins Medical Institutions  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Granger","sequence":"additional","affiliation":[{"name":"Center for Statistical Analysis and Research New England Research Institutes  Watertown Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrill J.","family":"Slichter","sequence":"additional","affiliation":[{"name":"Puget Sound Blood Center University of Washington Medical Center Fred Hutchinson Cancer Research Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904084"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(74)90015-0"},{"key":"e_1_2_8_5_1","unstructured":"US Department of Health and Human Services National Institutes of Health National Cancer Institute.Common Terminology Criteria for Adverse Events (CTCAE) version 3.0.2003. 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