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Recent advances in elucidating the pathophysiology of acquired <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> have led to new testing that we have incorporated into our current management of patients with suspected acquired <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>. Despite these developments, much of the treatment for acquired <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> beyond therapeutic plasma exchange (<jats:styled-content style=\"fixed-case\">TPE<\/jats:styled-content>) is based on low\u2010quality evidence. Our group has a sustained interest in studying and optimizing the use of <jats:styled-content style=\"fixed-case\">TPE<\/jats:styled-content>, along with other concurrent therapies, in acquired <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> patients. Described herein is a summary of how our apheresis consult service approaches requests for <jats:styled-content style=\"fixed-case\">TPE<\/jats:styled-content> in patients with suspected acquired <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/trf.12794","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T09:11:08Z","timestamp":1406625068000},"page":"2375-2382","source":"Crossref","is-referenced-by-count":14,"title":["How we approach an acquired thrombotic thrombocytopenic purpura patient"],"prefix":"10.1111","volume":"54","author":[{"given":"Jay S.","family":"Raval","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina  Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall A.","family":"Mazepa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine 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