{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:42:58Z","timestamp":1758814978761},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1 alloimmunization is a major cause of hemolytic disease of the fetus and newborn (<jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>). While select countries have guidelines for preventing transfusion\u2010associated<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1 alloimmunization, the<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tates does not.<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>eth<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>srael<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>eaconess<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter instituted a policy in<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2009 whereby women not more than 50 years of age on the obstetric service were transfused<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1\u2010negative red blood cells (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s). We sought to determine compliance and impact for prevention of<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1 alloimmunization and<jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>All women not more than 50 years of age without anti\u2010<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>transfused<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s during an obstetric admission from<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 9, 2009, to<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 9, 2012, were identified (227). Adherence to policy, factors contributing to nonadherence, and subsequent impact were evaluated. For comparison, all cases of anti\u2010<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>detection in women not more than 50 years of age admitted to nonobstetric services and all cases of transfusion\u2010associated<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1 alloimmunization in women not more than 50 years of age during the 10 years prior were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four percent received only<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1\u2010negative units. Three (1.3%) women not more than 50 years of age on the obstetric service were identified with anti\u2010<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>, while 17 (1.5%) women not more than 50 years of age on nonobstetric services had anti\u2010<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>detected; only five of 20 had a prior<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>transfusion. In the 10 years prior, there were 27 cases of transfusion\u2010associated<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1 alloimmunization in women not more than 50 years of age. There were no cases of<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>in either period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the findings demonstrate feasibility of providing<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1\u2010negative<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s to women of childbearing potential, evidence for clinical benefit is lacking. The low prevalence of<jats:styled-content style=\"fixed-case\">KEL<\/jats:styled-content>1 in blood donors, the lack of significant differences in alloimmunization rates, and no cases of<jats:styled-content style=\"fixed-case\">HDFN<\/jats:styled-content>during the study period questions the clinical benefit of such a policy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12814","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T16:30:39Z","timestamp":1407947439000},"page":"599-604","source":"Crossref","is-referenced-by-count":14,"title":["Provision of<scp>KEL<\/scp>1\u2010negative blood to obstetric patients: a 3\u2010year single\u2010institution retrospective review"],"prefix":"10.1111","volume":"55","author":[{"given":"Kerry L.","family":"O'Brien","sequence":"first","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center Boston Massachusetts"},{"name":"Department of Pathology Harvard Medical School Boston 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