{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:09:22Z","timestamp":1792300162642,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Immune hemolytic anemia is a well\u2010known complication after allogeneic hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Posttransplant hemolytic anemia results in increased red blood cell transfusions and medical sequelae including iron overload.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>We present a case report of immune hemolytic anemia that occurred after allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> from an <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> major\u2013mismatched, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010matched unrelated donor. The patient had high anti\u2010donor <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> type antibodies that were unresponsive to treatment with steroids and rituximab, resulting in persistent transfusion dependence. A detailed time course of anti\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> titers, plasma cell content of the marrow, and <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell content of the blood is presented. Treatment with bortezomib, a protease inhibitor, eliminated residual host\u2010type plasma cells secreting anti\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and restored normal donor\u2010derived erythropoiesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This report, and a review of literature for treatment of immune hemolytic anemia after allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, supports the utility of bortezomib as plasma cell\u2013targeted therapy in this setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12815","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T02:31:31Z","timestamp":1409020291000},"page":"259-264","source":"Crossref","is-referenced-by-count":35,"title":["Successful treatment of severe immune hemolytic anemia after allogeneic stem cell transplantation with bortezomib: report of a case and review of literature"],"prefix":"10.1111","volume":"55","author":[{"given":"Sakura","family":"Hosoba","sequence":"first","affiliation":[{"name":"Winship Cancer Institute Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Jaye","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Roback","sequence":"additional","affiliation":[{"name":"Center for Transfusion and Cellular Therapies Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund K.","family":"Waller","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute Emory University School of Medicine  Atlanta Georgia"},{"name":"Center for Transfusion and Cellular Therapies Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38398222864.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700677"},{"key":"e_1_2_6_4_1","first-page":"1093","article-title":"Autoimmune hemolytic anemia following T cell\u2010depleted allogeneic bone marrow transplantation","volume":"17","author":"Drobyski WR","year":"1996","journal-title":"Bone Marrow 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