{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:40:28Z","timestamp":1762875628249},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Background<\/jats:title>Transfusion of ABO<\/jats:styled-content>\u2010incompatible platelets (PLTs<\/jats:styled-content>) is associated with reduced PLT<\/jats:styled-content> recovery and a risk of transfusion reactions. However, a policy of transfusing only ABO<\/jats:styled-content>\u2010identical PLTs<\/jats:styled-content> may increase wastage due to product outdating. A prospective study attempting to compare the effects of different ABO<\/jats:styled-content> compatibility strategies could be costly and disruptive to a blood bank's operations.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>We designed a \u201cvirtual blood bank,\u201d a stochastic computer program that models the stocking and release of products to meet demand for PLT<\/jats:styled-content> transfusion in a simulated hospital population. ABO<\/jats:styled-content>\u2010nonidentical transfusions (ABOni<\/jats:styled-content>), outdates, and inventory shortages were recorded and compared under two different transfusion strategies: ABO<\/jats:styled-content>\u2010F<\/jats:styled-content>irst, a strategy that prioritizes transfusion of ABO<\/jats:styled-content>\u2010identical PLTs<\/jats:styled-content>, and A<\/jats:styled-content>ge\u2010F<\/jats:styled-content>irst, a strategy that minimizes outdating by transfusing products closest to expiration.<\/jats:p><\/jats:sec>Results<\/jats:title>The ABO<\/jats:styled-content>\u2010F<\/jats:styled-content>irst strategy resulted in fewer ABO<\/jats:styled-content>ni but more outdates than the A<\/jats:styled-content>ge\u2010F<\/jats:styled-content>irst strategy. Under conditions that mimic a large hospital blood bank, the ABO<\/jats:styled-content>\u2010F<\/jats:styled-content>irst strategy was more cost\u2010effective overall than the A<\/jats:styled-content>ge\u2010F<\/jats:styled-content>irst strategy if avoiding an ABO<\/jats:styled-content>ni is valued at more than $19 to $26. For a small blood bank, the ABO<\/jats:styled-content>\u2010F<\/jats:styled-content>irst strategy was more cost\u2010effective if avoiding an ABO<\/jats:styled-content>ni is valued at more than $104 to $123.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Based on a virtual blood bank computer simulation, the cost of avoiding an ABO<\/jats:styled-content>ni using the ABO<\/jats:styled-content>\u2010F<\/jats:styled-content>irst strategy varies greatly by size of institution. Individual blood banks must carefully consider these management strategies to determine the most cost\u2010effective solution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12831","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T02:45:27Z","timestamp":1409625927000},"page":"348-356","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of two platelet transfusion strategies to minimize ABO<\/scp>\u2010nonidentical transfusion, outdating, and shortages using a computer\u2010simulated \u201cvirtual blood bank\u201d"],"prefix":"10.1111","volume":"55","author":[{"suffix":"Jr.","given":"Ronald","family":"Jackups","sequence":"first","affiliation":[{"name":"Department of Pathology & Immunology Washington University School of Medicine St Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kymes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science Washington University School of Medicine St Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328358b135"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02273.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02602.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393165"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01914.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1993.tb00150.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb04356.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00037.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-909-TOPCAP"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03596.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2009.10.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03535.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38198141498.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060790.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01464.x"},{"key":"e_1_2_8_17_1","first-page":"35","volume-title":"Standards for blood banks and transfusion services","author":"American Association of Blood Banks","year":"2012"},{"key":"e_1_2_8_18_1","unstructured":"2011 College of American Pathologists Northfield (IL) College of American Pathologists Transfusion medicine checklist 31 32"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02759.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03329.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03338.x"},{"key":"e_1_2_8_22_1","volume-title":"Probability and statistics","author":"DeGroot MH","year":"1986"},{"key":"e_1_2_8_23_1","unstructured":"Department of Health and Human Services.The 2011 national blood collection and utilization survey report. 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