{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:53:37Z","timestamp":1777348417518,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gordon and Llura Gund Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>orrelia miyamotoi<\/jats:italic>, a recently discovered relapsing fever spirochete, occurs in hard\u2010bodied ticks wherever <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>yme disease is endemic. Human infection is associated with relapsing fever and can cause meningoencephalitis in immunocompromised patients. A few cases of transfusion transmission of other relapsing fever spirochete species have been reported but none for <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009miyamotoi<\/jats:italic>. Our objective was to determine whether <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009miyamotoi<\/jats:italic> transfusion transmission could occur in a murine transfusion model. Herein, we report transfusion transmission of <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009miyamotoi<\/jats:italic> through fresh or stored red blood cells (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s) in a mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Inbred mice were transfused with <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009miyamotoi<\/jats:italic>\u2013infected murine blood that was either freshly collected or stored for 7 days before transfusion. Recipient blood was then longitudinally examined after transfusion by smear and wet mount for evidence of spirochetemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Motile spirochetes were observed in immunocompromised (<jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content>) mouse recipients for 28 days after transfusion of both fresh and stored murine <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009miyamotoi<\/jats:italic>\u2013infected <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s. Transient spirochetemia was observed in immunocompetent <jats:styled-content style=\"fixed-case\">DBA<\/jats:styled-content>\/2 and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice, with spirochete clearance occurring within 5 days after transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data demonstrate that transfusion transmission of <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>.\u2009miyamotoi<\/jats:italic> can occur in mice and suggest that it also may occur in humans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12879","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T04:16:22Z","timestamp":1411532182000},"page":"593-597","source":"Crossref","is-referenced-by-count":20,"title":["Blood transfusion transmission of the tick\u2010borne relapsing fever spirochete 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