{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:42:33Z","timestamp":1791776553543,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Background<\/jats:title>Transfusion of ABO<\/jats:styled-content> major\u2013incompatible red blood cells (RBCs<\/jats:styled-content>) can activate the complement system and can cause severe and even lethal acute hemolytic reactions. The activation of the complement system with formation of C<\/jats:styled-content>3a and C<\/jats:styled-content>5a (anaphylatoxins) and the release of hemoglobin from the lysed RBCs<\/jats:styled-content> are thought to mediate clinical signs like fever, hypotension, pain, and acute renal failure. Therapeutic inhibition of the complement cascade in case of ABO<\/jats:styled-content>\u2010incompatible RBC<\/jats:styled-content> transfusion would be desirable to ameliorate the signs and symptoms and to improve the outcome of the reaction.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>A patient with blood group B<\/jats:styled-content> was erroneously transfused with a unit of group A<\/jats:styled-content>2<\/jats:sub> RBCs<\/jats:styled-content>. Within 1\u2009hour after transfusion she received eculizumab, a monoclonal antibody that binds to the complement component C<\/jats:styled-content>5 and blocks its cleavage. Clinical and immunohematologic observations are reported here.<\/jats:p><\/jats:sec>Results<\/jats:title>Hemoglobinemia and hemoglobinuria were present for several hours after transfusion, but she developed no hypotension, no renal failure, and no disseminated intravascular coagulation. As shown by flow cytometry, group A<\/jats:styled-content> cells survived in the peripheral blood for more than 75 days. No immunoglobulin\u2009G<\/jats:styled-content> was detectable by column agglutination technique on these cells.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A low isoagglutinin titer and blood group A<\/jats:styled-content>2<\/jats:sub> of the erroneously transfused cells most likely were the reason for the absence of clinical signs during and immediately after the ABO<\/jats:styled-content>\u2010incompatible transfusion. In the further course, eculizumab successfully protected the incompatible RBCs<\/jats:styled-content> from hemolysis for several weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12882","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T04:16:43Z","timestamp":1411532203000},"page":"605-610","source":"Crossref","is-referenced-by-count":35,"title":["Successful use of eculizumab for treatment of an acute hemolytic reaction after ABO<\/scp>\u2010incompatible red blood cell transfusion"],"prefix":"10.1111","volume":"55","author":[{"given":"Christof","family":"Weinstock","sequence":"first","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2013Hessen Institute of Transfusion Medicine University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"M\u00f6hle","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Weisel","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"H\u00f6chsmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2013Hessen Institute of Transfusion Medicine University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Schrezenmeier","sequence":"additional","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2013Hessen Institute of Transfusion Medicine University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Kanz","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Serious Hazards of Transfusion Steering Committee.Serious hazards of transfusion: annual report 2012. 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