{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:47:15Z","timestamp":1781840835214,"version":"3.54.5"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T00:00:00Z","timestamp":1415145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This work was supported by Terumo BCT, in the form of reagents, equipment and grants.","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Background<\/jats:title>Arboviruses are an emerging threat to transfusion safety and rates of infection are likely to increase with the increased rainfall associated with climate change. Arboviral infections are common in A<\/jats:styled-content>ustralia, where R<\/jats:styled-content>oss R<\/jats:styled-content>iver virus (RRV<\/jats:styled-content>), B<\/jats:styled-content>armah F<\/jats:styled-content>orest virus (BFV<\/jats:styled-content>), and M<\/jats:styled-content>urray V<\/jats:styled-content>alley encephalitis virus (MVEV<\/jats:styled-content>), among others, have the potential to cause disease in humans. The use of pathogen reduction technology (PRT<\/jats:styled-content>) may be an alternative approach for blood services to manage the risk of arboviral transfusion transmission. In this study, the effectiveness of the M<\/jats:styled-content>irasol PRT<\/jats:styled-content> (T<\/jats:styled-content>erumo BCT<\/jats:styled-content>) system at inactivating RRV<\/jats:styled-content>, BFV<\/jats:styled-content>, and MVEV<\/jats:styled-content> in buffy coat (BC<\/jats:styled-content>)\u2010derived platelets (PLTs<\/jats:styled-content>) was investigated.<\/jats:p><\/jats:sec>Study Design and Methods<\/jats:title>BC<\/jats:styled-content>\u2010derived PLT<\/jats:styled-content> concentrates in additive solution (SSP<\/jats:styled-content>+) were spiked with RRV<\/jats:styled-content>, BFV<\/jats:styled-content>, or MVEV<\/jats:styled-content> and then treated with the M<\/jats:styled-content>irasol PRT<\/jats:styled-content> system. The level of infectious virus was determined before and after treatment, and the reduction in viral infectivity was calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Treatment with PRT<\/jats:styled-content> (M<\/jats:styled-content>irasol) reduced the amount of infectious virus of all three arboviruses. The greatest level of inactivation was observed for RRV<\/jats:styled-content> (2.33 log; 99.25%), followed by BFV<\/jats:styled-content> (1.97 log; 98.68%) and then MVEV<\/jats:styled-content> (1.83 log; 98.42%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study demonstrates that treatment of PLT<\/jats:styled-content> concentrates with PRT<\/jats:styled-content> (M<\/jats:styled-content>irasol) reduces the infectious levels of RRV<\/jats:styled-content>, BFV<\/jats:styled-content>, and MVEV<\/jats:styled-content>. The relevance of the level of reduction required to prevent disease transmission by transfusion has not been fully defined and requires further investigation. In the face of a changing climate, with its associated threat to blood safety, PRT<\/jats:styled-content> represents a proactive approach for maintaining blood safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12899","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T07:01:26Z","timestamp":1415170886000},"page":"824-831","source":"Crossref","is-referenced-by-count":19,"title":["The effect of riboflavin and ultraviolet light on the infectivity of arboviruses"],"prefix":"10.1111","volume":"55","author":[{"given":"Helen M.","family":"Faddy","sequence":"first","affiliation":[{"name":"Research and Development Australian Red Cross Blood Service Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Prow","sequence":"additional","affiliation":[{"name":"Australian Infectious Disease Research Centre School of Chemistry and Molecular Biosciences The University of Queensland Brisbane Queensland 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