{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:53:38Z","timestamp":1777348418801,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Background<\/jats:title>Human granulocytic anaplasmosis (HGA<\/jats:styled-content>) is an acute nonspecific febrile illness caused by the bacterium A<\/jats:styled-content>naplasma phagocytophilum<\/jats:italic>. Although usually transmitted via tick bite, HGA<\/jats:styled-content> may rarely also be acquired through transfusion. HGA<\/jats:styled-content> during pregnancy may pose significant gestational risks due to altered maternal immune status and the potential for perinatal transmission.<\/jats:p><\/jats:sec>Case Report<\/jats:title>A pregnant 34\u2010year\u2010old M<\/jats:styled-content>assachusetts woman with \u03b2\u2010thalassemia trait was diagnosed at 32 weeks of gestation with transfusion\u2010associated HGA<\/jats:styled-content> (TAHGA<\/jats:styled-content>) after receiving nine leukoreduced red blood cell transfusions. She was successfully treated with rifampin therapy and gave birth to a healthy child who tested negative for HGA<\/jats:styled-content> after delivery. An implicated blood donor was subsequently identified through physician collaboration with the regional A<\/jats:styled-content>merican R<\/jats:styled-content>ed C<\/jats:styled-content>ross and M<\/jats:styled-content>assachusetts D<\/jats:styled-content>epartment of P<\/jats:styled-content>ublic H<\/jats:styled-content>ealth.<\/jats:p><\/jats:sec>Discussion<\/jats:title>This is the 11th reported case of HGA<\/jats:styled-content> in pregnancy and is at least the sixth known case in which leukoreduction did not prevent TAHGA<\/jats:styled-content>. As seen in this case, nonspecific symptomatology of variable onset can impede diagnosis and treatment. This may increase risk of poor outcomes in maternal HGA<\/jats:styled-content> patients. Cases of TAHGA<\/jats:styled-content>, although currently uncommon, may increase as the incidence of HGA<\/jats:styled-content> in certain parts of the country increases.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Heightened cross\u2010institutional awareness of the potential risk of TAHGA<\/jats:styled-content> is warranted. Clinicians need to consider transfusion\u2010associated infections when fever occurs in a transfusion recipient. This case provides additional evidence that leukoreduction does not obviate risk of A<\/jats:styled-content>.\u2009phagocytophilum<\/jats:italic> contamination of donated blood components.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.12908","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T08:03:05Z","timestamp":1415692985000},"page":"719-725","source":"Crossref","is-referenced-by-count":15,"title":["Transfusion\u2010associated A<\/scp>naplasma phagocytophilum<\/i> infection in a pregnant patient with thalassemia trait: a case report"],"prefix":"10.1111","volume":"55","author":[{"given":"Kelsey","family":"Shields","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts"},{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center Harvard Medical School Boston 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