{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:40:00Z","timestamp":1791859200379,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Platelet (\n                      <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\n                      ) transfusion is indicated either prophylactically or therapeutically to reduce the risk of bleeding or to control active bleeding. Significant uncertainty exists regarding the appropriate use of\n                      <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\n                      transfusion and the optimal threshold for transfusion in various settings. We formulated 12 key questions to assess the role of\n                      <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\n                      transfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Methods<\/jats:title>\n                    <jats:p>\n                      We performed a systematic review (\n                      <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\n                      ) of randomized controlled trials (\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s) and observational studies. A comprehensive search of\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      ub\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      ed,\n                      <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                      eb of\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      cience, and\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ochrane registry of controlled trials was performed. Methodologic quality of included studies was assessed and a meta\u2010analysis was performed if more than two studies with similar designs were identified for a specific question.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s and 55 observational studies were included in the final\n                      <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>\n                      . Results from\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s showed a beneficial effect of prophylactic compared with therapeutic transfusion for the prevention of significant bleeding in patients with hematologic disorders undergoing chemotherapy or stem cell transplantation. We found no difference in significant bleeding events related to the\n                      <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\n                      count threshold for transfusion or the dose of\n                      <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\n                      s transfused. Overall methodologic quality of\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      s was moderate. Results from observational studies showed no evidence that\n                      <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\n                      transfusion prevented significant bleeding in patients undergoing central venous catheter insertions, lumbar puncture, or other surgical procedures. The methodologic quality of observational studies was very low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We provide a comprehensive assessment of evidence on the use of\n                      <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>\n                      transfusions in a variety of clinical settings. Our report summarizes current knowledge and identifies gaps to be addressed in future research.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.12943","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T05:43:06Z","timestamp":1415770986000},"page":"1116-1127","source":"Crossref","is-referenced-by-count":149,"title":["Platelet transfusion: a systematic review of the clinical evidence"],"prefix":"10.1111","volume":"55","author":[{"given":"Ambuj","family":"Kumar","sequence":"first","affiliation":[{"name":"Division of Evidence\u2010Based Medicine Department of Internal Medicine Morsani College of Medicine University of South Florida  Tampa Florida"},{"name":"Moffitt Cancer Center  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mhaskar","sequence":"additional","affiliation":[{"name":"Division of Evidence\u2010Based Medicine Department of Internal Medicine Morsani College of Medicine University of South Florida  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda J.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine  St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron A.R.","family":"Tobian","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kleinman","sequence":"additional","affiliation":[{"name":"Center for Blood Research The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Gernsheimer","sequence":"additional","affiliation":[{"name":"University of Washington Medical Center and Seattle Cancer Care Alliance  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Tinmouth","sequence":"additional","affiliation":[{"name":"Ottawa Hospital and Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Djulbegovic","sequence":"additional","affiliation":[{"name":"Division of Evidence\u2010Based Medicine Department of Internal Medicine Morsani College of Medicine University of South Florida  Tampa Florida"},{"name":"Moffitt Cancer Center  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"AABB Platelet Transfusion Guidelines Panel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WhitakerB HinkinsS.The 2011 national blood collection and utilization survey report. Rockville (MD): US Department of Health and Human Services;2013."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.04.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.33293158052.x"},{"key":"e_1_2_7_5_1","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins JP","year":"2011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.11.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004269.pub3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38446.498542.8F"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1077"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_7_12_1","first-page":"285","volume-title":"Statistical methods for examining heterogeneity and combining results from several studies in meta\u2010analysis","author":"Deeks JJ","year":"2008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V120.21.1.1","article-title":"The effect of a no\u2010prophylactic versus prophylactic platelet transfusion strategy on bleeding in patients with hematological malignancies and severe thrombocytopenia (TOPPS trial). A randomized controlled, non\u2010inferiority trial [abstract]","volume":"120","author":"Stanworth SJ","year":"2012","journal-title":"Blood"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60689-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830120406"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90505-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04157.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.1143"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372602"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2002.v8.pm12434952"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1973.tb05490.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-178236"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904084"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04118.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80457-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.204.1.9205228"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2168::AID-CNCR2820491031>3.0.CO;2-O"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20201"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.17.2222"},{"key":"e_1_2_7_30_1","first-page":"I111","article-title":"Prophylactic platelet transfusions before lumbar puncture","volume":"77","author":"Kitanovski L","year":"2008","journal-title":"Zdravniski Vestnik\u2010Slovenian Med J"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06433.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0707-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05178.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00970.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830260205"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03322.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480907501115"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181848caa"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000151671.35280.8B"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318185e234"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.06.009"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318220ad7e"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.10.007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X459129"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.11.JNS12622"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21279"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02082.x"},{"key":"e_1_2_7_48_1","article-title":"The potential risks of platelet transfusions (PT) in patients with thrombotic thrombocytopenia purpura\u2013hemolytic uremic syndrome (TTP\u2010HUS)","volume":"96","author":"Kennedy KA","year":"2000","journal-title":"Blood"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31291142949.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19961101)78:9<2025::AID-CNCR26>3.0.CO;2-Y"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.1.185"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050884"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2009.10.032"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00552-3"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2007.06.035"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03147.x"},{"key":"e_1_2_7_57_1","first-page":"684","article-title":"Comparison of \u201cprophylactic\u201d and \u201ctherapeutic\u201d single\u2010donor platelet transfusions in patients with acute leukemia","volume":"50","author":"Sintnicolaas K","year":"1981","journal-title":"Br J Haematol"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1841"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9619-3"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.550939"},{"key":"e_1_2_7_61_1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1182\/blood.V116.21.3809.3809","article-title":"Platelet transfusions in patients with immune thrombocytopenic purpura (ITP)\u2014evaluation of the current nationwide inpatient hospital practices","volume":"116","author":"Tran L","year":"2010","journal-title":"Blood"},{"key":"e_1_2_7_62_1","first-page":"81","article-title":"The feasibility of laparoscopic splenectomy for ITP patients without preoperative platelet transfusion","volume":"59","author":"Wu Z","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.06.031"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90664-9"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245330701255213"},{"key":"e_1_2_7_66_1","first-page":"129","article-title":"Intracranial haemorrhage among Chinese children with immune thrombocytopenia in a Hong Kong regional hospital","volume":"19","author":"So MY","year":"2013","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21060"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-06-0418"},{"key":"e_1_2_7_69_1","volume-title":"Blood transfusion guideline","year":"2011"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-435693"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2089"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-1-201206190-00429"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02632.x"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7003.485"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.12943","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.12943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:00:47Z","timestamp":1695477647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.12943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,12]]},"references-count":73,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/trf.12943"],"URL":"https:\/\/doi.org\/10.1111\/trf.12943","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725233381.793527633","asserted-by":"object"}]},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,12]]}}}